Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct;24(10):1454-1460.
doi: 10.1038/s41556-022-00978-w. Epub 2022 Sep 12.

Insights and opportunities at the crossroads of cancer and neuroscience

Chenchen Pan  1   2 , Frank Winkler  3   4
Affiliations
Review

Insights and opportunities at the crossroads of cancer and neuroscience

Chenchen Pan et al. Nat Cell Biol. 2022 Oct.

Abstract

The biological and pathological importance of mutual interactions between the nervous system and cancer have become increasingly evident. The emerging field of cancer neuroscience aims to decipher key signalling factors of cancer-nervous system crosstalk and to exploit these modulators as targets for improved anticancer therapies. Here we discuss the key achievements in cancer neuroscience research, inspire further interactions on a variety of related research topics, and provide a roadmap for future studies.

PubMed Disclaimer

References

    1. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011). - PubMed
    1. Monje, M. et al. Roadmap for the emerging field of cancer neuroscience. Cell 181, 219–222 (2020). - PubMed - PMC - DOI
    1. Faulkner, S., Jobling, P., March, B., Jiang, C. C. & Hondermarck, H. Tumor neurobiology and the war of nerves in cancer. Cancer Discov. 9, 702–710 (2019). - PubMed - DOI
    1. Reiche, E. M., Nunes, S. O. & Morimoto, H. K. Stress, depression, the immune system and cancer. Lancet Oncol. 5, 617–625 (2004). - PubMed - DOI
    1. Li, L. & Hanahan, D. Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion. Cell 153, 86–100 (2013). - PubMed - DOI

Publication types