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Review
. 2022 Dec;49(12):11535-11546.
doi: 10.1007/s11033-022-07820-4. Epub 2022 Sep 12.

Non-coding RNA in idiopathic interstitial pneumonia and Covid-19 pulmonary fibrosis

Mohammad Shadab Ali  1 , Jay Singh  2 , Md Tanjim Alam  3 , Anita Chopra  2 , Sudheer Arava  4 , Ashu Seith Bhalla  5 , Saurabh Mittal  1 , Anant Mohan  1 , Dipendra K Mitra  6 , Vijay Hadda  7
Affiliations
Review

Non-coding RNA in idiopathic interstitial pneumonia and Covid-19 pulmonary fibrosis

Mohammad Shadab Ali et al. Mol Biol Rep. 2022 Dec.

Abstract

Pulmonary fibrosis is the key feature of majority of idiopathic interstitial pneumonias (IIPs) as well as many patients with post-COVID-19. The pathogenesis of pulmonary fibrosis is a complex molecular process that involves myriad of cells, proteins, genes, and regulatory elements. The non-coding RNA mainly miRNA, circRNA, and lncRNA are among the key regulators of many protein coding genes and pathways that are involved in pulmonary fibrosis. Identification and molecular mechanisms, by which these non-coding RNA molecules work, are crucial to understand the molecular basis of the disease. Additionally, elucidation of molecular mechanism could also help in deciphering a potential diagnostic/prognostic marker as well as therapeutic targets for IIPs and post-COVID-19 pulmonary fibrosis. In this review, we have provided the latest findings and discussed the role of these regulatory elements in the pathogenesis of pulmonary fibrosis associated with Idiopathic Interstitial Pneumonia and Covid-19.

Keywords: Covid-19; IIP; Pulmonary fibrosis; circRNA; lncRNA; miRNA.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Biogenesis and Major functions of ncRNAs
See this image and copyright information in PMC

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