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Comment
. 2022 Sep;28(9):1751-1752.
doi: 10.1038/s41591-022-01983-0.

A combined stem-cell-gene therapy strategy for ALS

Hideyuki Okano  1   2
Affiliations
Comment

A combined stem-cell-gene therapy strategy for ALS

Hideyuki Okano. Nat Med. 2022 Sep.
No abstract available

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Comment on

  • Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial.
    Baloh RH, Johnson JP, Avalos P, Allred P, Svendsen S, Gowing G, Roxas K, Wu A, Donahue B, Osborne S, Lawless G, Shelley B, Wheeler K, Prina C, Fine D, Kendra-Romito T, Stokes H, Manoukian V, Muthukumaran A, Garcia L, Bañuelos MG, Godoy M, Bresee C, Yu H, Drazin D, Ross L, Naruse R, Babu H, Macklin EA, Vo A, Elsayegh A, Tourtellotte W, Maya M, Burford M, Diaz F, Patil CG, Lewis RA, Svendsen CN. Baloh RH, et al. Nat Med. 2022 Sep;28(9):1813-1822. doi: 10.1038/s41591-022-01956-3. Epub 2022 Sep 5. Nat Med. 2022. PMID: 36064599 Free PMC article. Clinical Trial.

References

    1. Okano, H. & Morimoto, S. Cell Stem Cell. 29, 189–208 (2022). - DOI
    1. Lepore, A. C. et al. Exp. Neurol. 211, 423–432 (2008). - DOI
    1. Lin, L. F. et al. Science 260, 1130–1132 (1993). - DOI
    1. Henderson, C. E. et al. Science 266, 1062–1064 (1994). - DOI
    1. Klein, S. M. et al. Hum. Gene Ther. 16, 509–521 (2005). - DOI

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