Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr;55(2):603-617.
doi: 10.4143/crt.2022.307. Epub 2022 Sep 6.

Descriptive Analysis of Gastric Cancer Mortality in Korea, 2000-2020

Tung Hoang  1   2 , Hyeongtaek Woo  1   3 , Sooyoung Cho  1   4 , Jeeyoo Lee  1 , Sayada Zartasha Kazmi  1 , Aesun Shin  1   2   5
Affiliations

Descriptive Analysis of Gastric Cancer Mortality in Korea, 2000-2020

Tung Hoang et al. Cancer Res Treat. 2023 Apr.

Abstract

Purpose: This study aimed to examine secular trends, age-period-cohort effects, and geographical differences in gastric cancer (GC) mortality in Korea.

Materials and methods: Using cause of death data from the Korean Statistical Information Service for GC from 2000 to 2020, we calculated average annual percentage changes (AAPCs) in the age-standardized mortality of GC in 17 cities and provinces through joinpoint regression. Decomposition of age, period, and cohort effects on GC mortality were elucidated by applying a log-linear model and an intrinsic estimate method. Spatial patterns and the degree of spatial clustering in 250 administrative regions were explored via Moran's I statistics. Stratification by sex was performed for all analyses.

Results: The age-standardized mortality of GC per 100,000 persons declined from 29.0 in 2000 to 7.9 in 2020 (AAPC, -6.28%). Age-period-cohort analyses of GC mortality showed a downward trend among five-year age groups from age 20-89 years across five-year periods from 2005-2020 and five-year birth cohorts from 1920-2000. Overall, the younger birth cohort showed lower mortality rates than the older cohort within the same period. In 2020, clusters of high GC mortality were observed in the central area for men (Chungcheongbuk, Jeollabuk, Gyeongsangbuk, and Gyeongsangnam) and in the eastern area for women (Gyeongsangbuk).

Conclusion: This study identified a downward trend in GC mortality among men and women from 2000 to 2020 in Korea. This trend was mainly attributed to birth cohort rather than period effects. Spatial analysis showed high GC mortality in the Chungcheong and Gyeongsangbuk areas.

Keywords: Age-period-cohort analysis; Gastric cancer mortality; Joinpoint regression; Korea; Spatial analysis.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest

Conflict of interest relevant to this article was not reported.

Figures

Fig. 1
Fig. 1
Trends of age-standardized mortality rates in Korea between 2000 and 2020.
Fig. 2
Fig. 2
Age, period, and birth cohort effects on gastric cancer mortality. (A) Age-specific gastric cancer mortality by period. (B) Age-specific gastric cancer mortality by birth cohort. (C) Period-specific gastric cancer mortality by birth cohort.
Fig. 3
Fig. 3
Model estimates for age-period-cohort effects on gastric cancer mortality.
Fig. 4
Fig. 4
Geographical distribution of age-standardized gastric cancer mortality rates (per 100,000 persons) in Korea, 2020.
Fig. 5
Fig. 5
Local Moran’s I cluster maps for the spatial association of age-standardized gastric cancer mortality rates in Korea, 2020.
See this image and copyright information in PMC

References

    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49. - PubMed
    1. Wong MCS, Huang J, Chan PS, Choi P, Lao XQ, Chan SM, et al. Global incidence and mortality of gastric cancer, 1980–2018. JAMA Netw Open. 2021;4:e2118457. - PMC - PubMed
    1. G. B. D. Stomach Cancer Collaborators The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017. Lancet Gastroenterol Hepatol. 2020;5:42–54. - PMC - PubMed
    1. Kim JH, Han KD, Lee JK, Kim HS, Cha JM, Park S, et al. Association between the National Cancer Screening Programme (NSCP) for gastric cancer and oesophageal cancer mortality. Br J Cancer. 2020;123:480–6. - PMC - PubMed
    1. Ministry of Health and Welfare Korea . National cancer screening guideline 2018. Sejong: Ministry of Health and Welfare; 2018.