Culture and causal inference: The impact of cultural differences on the generalisability of findings from Mendelian randomisation studies

Amy Campbell^{1

2}, Marcus R Munafò^{1

2}, Hannah M Sallis^{1

2

3}, Rebecca M Pearson^{4

5}, Daniel Smith^{1

6}

Affiliations

¹ MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UKamy.campbell@bristol.ac.uk.
² School of Psychological Science, University of Bristol, Bristol BS8 1TU, UKmarcus.munafo@bristol.ac.uk.
³ Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UKhannah.sallis@bristol.ac.uk.
⁴ Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
⁵ Faculty of Health, Psychology & Social Care, Manchester Metropolitan University, Manchester M15 6GX, UKr.pearson@mmu.ac.uk.
⁶ Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.dan.smith@bristol.ac.uk.

PMID: 36098429
DOI: 10.1017/S0140525X21001795

Comment

Culture and causal inference: The impact of cultural differences on the generalisability of findings from Mendelian randomisation studies

Amy Campbell et al. Behav Brain Sci. 2022.

. 2022 Sep 13:45:e158.

doi: 10.1017/S0140525X21001795.

Authors

Amy Campbell^{1

2}, Marcus R Munafò^{1

2}, Hannah M Sallis^{1

2

3}, Rebecca M Pearson^{4

5}, Daniel Smith^{1

6}

Affiliations

¹ MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UKamy.campbell@bristol.ac.uk.
² School of Psychological Science, University of Bristol, Bristol BS8 1TU, UKmarcus.munafo@bristol.ac.uk.
³ Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UKhannah.sallis@bristol.ac.uk.
⁴ Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
⁵ Faculty of Health, Psychology & Social Care, Manchester Metropolitan University, Manchester M15 6GX, UKr.pearson@mmu.ac.uk.
⁶ Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.dan.smith@bristol.ac.uk.

PMID: 36098429
DOI: 10.1017/S0140525X21001795

Abstract

Cultural effects can influence the results of causal genetic analyses, such as Mendelian randomisation, but the potential influences of culture on genotype-phenotype associations are not currently well understood. Different genetic variants could be associated with different phenotypes in different populations, or culture could confound or influence the direction of the association between genotypes and phenotypes in different populations.

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Comment in

Integrating cultural evolution and behavioral genetics.
Uchiyama R, Spicer R, Muthukrishna M. Uchiyama R, et al. Behav Brain Sci. 2022 Sep 13;45:e182. doi: 10.1017/S0140525X22000036. Behav Brain Sci. 2022. PMID: 36098400

Comment on

Cultural evolution of genetic heritability.
Uchiyama R, Spicer R, Muthukrishna M. Uchiyama R, et al. Behav Brain Sci. 2021 May 21;45:e152. doi: 10.1017/S0140525X21000893. Behav Brain Sci. 2021. PMID: 34016199

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Culture and causal inference: The impact of cultural differences on the generalisability of findings from Mendelian randomisation studies

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Culture and causal inference: The impact of cultural differences on the generalisability of findings from Mendelian randomisation studies

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