Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan 15;207(2):211-214.
doi: 10.1164/rccm.202208-1470LE.

Progressive Interstitial Lung Disease in Relatives of Patients with Pulmonary Fibrosis

Jonathan A Rose  1 , Maria A Planchart Ferretto  1 , Anthony H Maeda  1 , Maria F Perez Garcia  2 , Nikkola E Carmichael  3 , Swati Gulati  1 , Mary B Rice  4 , Hilary J Goldberg  1 , Rachel K Putman  1 , Hiroto Hatabu  5 , Benjamin A Raby  3 , Ivan O Rosas  2 , Gary M Hunninghake  1
Affiliations

Progressive Interstitial Lung Disease in Relatives of Patients with Pulmonary Fibrosis

Jonathan A Rose et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Computed tomography scans of the chest from two relatives with interstitial lung abnormalities (ILA) and progression at the 2-year follow-up. The first participant with ILA at baseline and 2-year follow-up had radiologic progression, including worsening reticulations throughout the lungs (white arrows) and increased basilar traction bronchiolectasis (black arrow). At the 2-year follow-up, FVC had decreased by 7% and DlCO by 17%. The second participant was indeterminate for ILA at baseline but had ILA at the 2-year follow-up and radiologic progression, including new and increased areas of upper lobe and basilar reticulation (white arrows) as well as new basilar traction bronchiolectasis (black arrow). At the 2-year follow-up, FVC had decreased by 15% and DlCO by 16%.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hunninghake GM, Quesada-Arias LD, Carmichael NE, Martinez Manzano JM, Poli De Frías S, Baumgartner MA, et al. Interstitial lung disease in relatives of patients with pulmonary fibrosis. Am J Respir Crit Care Med . 2020;201:1240–1248. - PMC - PubMed
    1. Salisbury ML, Hewlett JC, Ding G, Markin CR, Douglas K, Mason W, et al. Development and progression of radiologic abnormalities in individuals at risk for familial interstitial lung disease. Am J Respir Crit Care Med . 2020;201:1230–1239. - PMC - PubMed
    1. Hatabu H, Hunninghake GM, Richeldi L, Brown KK, Wells AU, Remy-Jardin M, et al. Interstitial lung abnormalities detected incidentally on CT: a position paper from the Fleischner Society. Lancet Respir Med . 2020;8:726–737. - PMC - PubMed
    1. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, et al. COPDGene Investigators Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med . 2011;364:897–906. - PMC - PubMed
    1. Putman RK, Gudmundsson G, Axelsson GT, Hida T, Honda O, Araki T, et al. Imaging patterns are associated with interstitial lung abnormality progression and mortality. Am J Respir Crit Care Med . 2019;200:175–183. - PMC - PubMed

Publication types

MeSH terms