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Comment
. 2022 Sep 12;40(9):905-907.
doi: 10.1016/j.ccell.2022.08.020.

Targeting lineage plasticity overcomes chemoresistance

Seishi Ogawa  1
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Free article
Comment

Targeting lineage plasticity overcomes chemoresistance

Seishi Ogawa. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Wang et al. reveal that chemoresistant muscle-invasive bladder cancer is associated with partial squamous differentiation. Targeting of Cathepsin H overcomes this chemotherapy-induced semi-squamatization and promotes terminal squamous differentiation and tumor suppression.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

  • Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer.
    Wang M, Chen X, Tan P, Wang Y, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q, Wei Y, Liu Y, Chen C. Wang M, et al. Cancer Cell. 2022 Sep 12;40(9):1044-1059.e8. doi: 10.1016/j.ccell.2022.08.010. Cancer Cell. 2022. PMID: 36099882

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