. 2022 Sep 13;12(9):e063043.

doi: 10.1136/bmjopen-2022-063043.

Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study

Conor S Gillespie^{1

2}, Emily R Bligh³, Michael T C Poon^{4

5}, Georgios Solomou⁶, Abdurrahman I Islim^{7

8}, Mohammad A Mustafa^{9

2}, Ola Rominiyi^{10

11}, Sophie T Williams^{10

12}, Neeraj Kalra¹³, Ryan K Mathew^{13

14}, Thomas C Booth^{15

16}, Gerard Thompson^{17

18}, Paul M Brennan^{5

17}, Michael D Jenkinson^{9

2}; INTERVAL-GB Collaborative; British Neurosurgical Trainee Research Collaborative (BNTRC); Neurology and Neurosurgery Interest Group (NANSIG); Neurology and Neurosurgery Interest Group

Collaborators, Affiliations

Collaborators

Hidayatul Abdullmalek, Suhaib Abualsaud, Gideon Adegboyega, Chinelo Afulukwe, Ahmed Ahmed, Najma Ahmed, Michael Amoo, Abdelsalam Nedal Al-Sousi, Yahia Al-Tamimi, Ajitesh Anand, Prithvi Bahu, Neil Barua, Harsh Bhatt, Emily R Bligh, Peter Bodkin, Ion Boiangiu, Abbey Boyle, Christiaan Bredell, Paul M Brennan, Talhah Chaudri, Jeremy Cheong, Ana Cios, Iona Cleer, David Coope, Ian Coulter, Giles Critchley, Harriet Davis, Paolo Jose De Luna, Nayan Dey, Bea Duric, Abdullah Egiz, Justyna O Ekert, Chinedu Brian Egu, Jinendra Ekanayake, Anna Elso, Tomas Ferreira, Tom Flannery, Kwan Wai Fung, Rahul Ganguly, Conor S Gillespie, Sanay Goyal, Emily Hardman, Lauren Harris, Theodore Hirst, Kelvin Sunn Hoah, Sam Hodgson, Kismet Hossain-Ibrahim, Lena Mary Houlihan, Sami Squali Houssaini, Sadid Hoque, Dana Hutton, Kismet Hossain-Ibrahim, Abdurrahman I Islim, Mahnoor Javed, Michael D Jenkinson, Neeraj Kalra, Siddarth Kannan, Efthymia Maria Kapasouri, Andrew Keenlyside, Kristy Kehoe, Bharti Kewlani, Prerna Khanna, Rosaline de Koning, Kunalika Sathish Kumar, Ashvin Kuri, Simon Lammy, Eunkyung Lee, Robert Magouirk, Andrew J Martin, Riccardo Masina, Ryan K Mathew, Adele Mazzoleni, Patrick McAleavey, Gráinne McKenna, Daniel McSweeney, Saad Moughal, Mohammad A Mustafa, Engelbert Mthunzi, Trinh Ton Nu Ngoc, Shiva A Nischal, Michael O'Sullivan, Jay J Park, Jonathan Pesic-Smith, Peter Peterson, Isaac Phang, Puneet Plaha, Anand Pandit, Shyam Pujara, George E Richardson, Marwa Mohammed Elrasheed Saad, Shinjan Sangal, Veekshith Shetty, Natalie Simon, Robert Spencer, Rosa Sun, Irtiza Syed, Jesvin Tom Sunny, Anca-Mihaela Vasilica, Armin Nazari, Daniel O'Flaherty, Setthasorn Zhi Yang Ooi, Arslan Khaliq Raja, Daniele Ramsay, Renitha Reddi, Daniel Richardson, Elena Roman, Ola Rominiyi, Dorina Roy, Omar Salim, Jeremiah Samkutty, Jashan Selvakumar, Thomas Santarius, Avani Shanbhag, Stuart Smith, Agbolahan Sofela, Edward Jerome St George, Preethi Subramanian, Vaibhav Sundaresan, Kieron Sweeney, Boon Hoe Tan, Nicole Turnbull, Yuewei Tao, Lewis Thorne, Rebecca Tweedie, Anastasia Tzatzidou, Babar Vaqas, Sara Venturini, Kathrin Whitehouse, Peter Whitfield, Jack Wildman, Isabelle Williams, Karl Williams, Victoria Wykes, Tiffany Ts Ye, Kelvin Sunn Yap, Mahir Yousuff, Asaad Zulfiqar, Conor S Gillespie, Emily R Bligh, Michael T C Poon, Georgios Solomou, Melissa Gough, Abdurrahman I Islim, Christopher P Millward, Ola Rominiyi, Rasheed Zakaria, Paul M Brennan, Stephen J Price, Colin Watts, Sophie Camp, Thomas C Booth, Gerard Thompson, Samantha J Mills, Adam Waldman, Michael D Jenkinson, Michael T C Poon, Abdurrahman I Islim, Angelos Kolias, Julie Woodfield, Aswin Chari, Neeraj Kalra, Soham Bandyopadhyay, Robin Borchert, Rory Piper, Daniel M Fountain, Conor S Gillespie, Emily R Bligh, Soham Bandyopadhyay, Jay J Park, Setthasorn Zy Ooi, George E Richardson, Abigail Clynch, Oliver Burton, Avani Shanbhag, Moritz Steinruecke, William Bolton, Bharti Kewlani, Alvaro Yanez Touzet, Hannah Redpath, Seong Hoon Lee, Abdullah Egiz, Joshua Erhabor, Orla Mantle

Affiliations

¹ Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK hlcgill2@liv.ac.uk.
² The Walton Centre NHS Foundation Trust, Liverpool, UK.
³ Department of Neurosurgery, Institute of Neurological Sciences, Glasgow, UK.
⁴ Usher Institute, The University of Edinburgh, Edinburgh, UK.
⁵ Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
⁶ School of Clinical Medicine, University of Cambridge, Cambridge, UK.
⁷ Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Manchester, UK.
⁸ Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
⁹ Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
¹⁰ Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
¹¹ Department of Neuroscience, The University of Sheffield, Sheffield, UK.
¹² Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK.
¹³ Department of Neurosurgery, Centre for Neurosciences, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
¹⁴ School of Medicine, University of Leeds, Leeds, UK.
¹⁵ Department of Neuroradiology, King's College Hospital, London, UK.
¹⁶ School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
¹⁷ Department of Clinical Neurosciences, NHS Lothian, Edinburgh, UK.
¹⁸ Edinburgh Neuro-oncology Translational Imaging Research (ENTIRe), Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

PMID: 36100297
PMCID: PMC9472166
DOI: 10.1136/bmjopen-2022-063043

Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study

Conor S Gillespie et al. BMJ Open. 2022.

. 2022 Sep 13;12(9):e063043.

doi: 10.1136/bmjopen-2022-063043.

Authors

Collaborators

Hidayatul Abdullmalek, Suhaib Abualsaud, Gideon Adegboyega, Chinelo Afulukwe, Ahmed Ahmed, Najma Ahmed, Michael Amoo, Abdelsalam Nedal Al-Sousi, Yahia Al-Tamimi, Ajitesh Anand, Prithvi Bahu, Neil Barua, Harsh Bhatt, Emily R Bligh, Peter Bodkin, Ion Boiangiu, Abbey Boyle, Christiaan Bredell, Paul M Brennan, Talhah Chaudri, Jeremy Cheong, Ana Cios, Iona Cleer, David Coope, Ian Coulter, Giles Critchley, Harriet Davis, Paolo Jose De Luna, Nayan Dey, Bea Duric, Abdullah Egiz, Justyna O Ekert, Chinedu Brian Egu, Jinendra Ekanayake, Anna Elso, Tomas Ferreira, Tom Flannery, Kwan Wai Fung, Rahul Ganguly, Conor S Gillespie, Sanay Goyal, Emily Hardman, Lauren Harris, Theodore Hirst, Kelvin Sunn Hoah, Sam Hodgson, Kismet Hossain-Ibrahim, Lena Mary Houlihan, Sami Squali Houssaini, Sadid Hoque, Dana Hutton, Kismet Hossain-Ibrahim, Abdurrahman I Islim, Mahnoor Javed, Michael D Jenkinson, Neeraj Kalra, Siddarth Kannan, Efthymia Maria Kapasouri, Andrew Keenlyside, Kristy Kehoe, Bharti Kewlani, Prerna Khanna, Rosaline de Koning, Kunalika Sathish Kumar, Ashvin Kuri, Simon Lammy, Eunkyung Lee, Robert Magouirk, Andrew J Martin, Riccardo Masina, Ryan K Mathew, Adele Mazzoleni, Patrick McAleavey, Gráinne McKenna, Daniel McSweeney, Saad Moughal, Mohammad A Mustafa, Engelbert Mthunzi, Trinh Ton Nu Ngoc, Shiva A Nischal, Michael O'Sullivan, Jay J Park, Jonathan Pesic-Smith, Peter Peterson, Isaac Phang, Puneet Plaha, Anand Pandit, Shyam Pujara, George E Richardson, Marwa Mohammed Elrasheed Saad, Shinjan Sangal, Veekshith Shetty, Natalie Simon, Robert Spencer, Rosa Sun, Irtiza Syed, Jesvin Tom Sunny, Anca-Mihaela Vasilica, Armin Nazari, Daniel O'Flaherty, Setthasorn Zhi Yang Ooi, Arslan Khaliq Raja, Daniele Ramsay, Renitha Reddi, Daniel Richardson, Elena Roman, Ola Rominiyi, Dorina Roy, Omar Salim, Jeremiah Samkutty, Jashan Selvakumar, Thomas Santarius, Avani Shanbhag, Stuart Smith, Agbolahan Sofela, Edward Jerome St George, Preethi Subramanian, Vaibhav Sundaresan, Kieron Sweeney, Boon Hoe Tan, Nicole Turnbull, Yuewei Tao, Lewis Thorne, Rebecca Tweedie, Anastasia Tzatzidou, Babar Vaqas, Sara Venturini, Kathrin Whitehouse, Peter Whitfield, Jack Wildman, Isabelle Williams, Karl Williams, Victoria Wykes, Tiffany Ts Ye, Kelvin Sunn Yap, Mahir Yousuff, Asaad Zulfiqar, Conor S Gillespie, Emily R Bligh, Michael T C Poon, Georgios Solomou, Melissa Gough, Abdurrahman I Islim, Christopher P Millward, Ola Rominiyi, Rasheed Zakaria, Paul M Brennan, Stephen J Price, Colin Watts, Sophie Camp, Thomas C Booth, Gerard Thompson, Samantha J Mills, Adam Waldman, Michael D Jenkinson, Michael T C Poon, Abdurrahman I Islim, Angelos Kolias, Julie Woodfield, Aswin Chari, Neeraj Kalra, Soham Bandyopadhyay, Robin Borchert, Rory Piper, Daniel M Fountain, Conor S Gillespie, Emily R Bligh, Soham Bandyopadhyay, Jay J Park, Setthasorn Zy Ooi, George E Richardson, Abigail Clynch, Oliver Burton, Avani Shanbhag, Moritz Steinruecke, William Bolton, Bharti Kewlani, Alvaro Yanez Touzet, Hannah Redpath, Seong Hoon Lee, Abdullah Egiz, Joshua Erhabor, Orla Mantle

Affiliations

¹ Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK hlcgill2@liv.ac.uk.
² The Walton Centre NHS Foundation Trust, Liverpool, UK.
³ Department of Neurosurgery, Institute of Neurological Sciences, Glasgow, UK.
⁴ Usher Institute, The University of Edinburgh, Edinburgh, UK.
⁵ Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
⁶ School of Clinical Medicine, University of Cambridge, Cambridge, UK.
⁷ Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Manchester, UK.
⁸ Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
⁹ Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
¹⁰ Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
¹¹ Department of Neuroscience, The University of Sheffield, Sheffield, UK.
¹² Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK.
¹³ Department of Neurosurgery, Centre for Neurosciences, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
¹⁴ School of Medicine, University of Leeds, Leeds, UK.
¹⁵ Department of Neuroradiology, King's College Hospital, London, UK.
¹⁶ School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
¹⁷ Department of Clinical Neurosciences, NHS Lothian, Edinburgh, UK.
¹⁸ Edinburgh Neuro-oncology Translational Imaging Research (ENTIRe), Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

PMID: 36100297
PMCID: PMC9472166
DOI: 10.1136/bmjopen-2022-063043

Abstract

Introduction: Glioblastoma is the most common malignant primary brain tumour with a median overall survival of 12-15 months (range 6-17 months), even with maximal treatment involving debulking neurosurgery and adjuvant concomitant chemoradiotherapy. The use of postoperative imaging to detect progression is of high importance to clinicians and patients, but currently, the optimal follow-up schedule is yet to be defined. It is also unclear how adhering to National Institute for Health and Care Excellence (NICE) guidelines-which are based on general consensus rather than evidence-affects patient outcomes such as progression-free and overall survival. The primary aim of this study is to assess MRI monitoring practice after surgery for glioblastoma, and to evaluate its association with patient outcomes.

Methods and analysis: ImagiNg Timing aftER surgery for glioblastoma: an eVALuation of practice in Great Britain and Ireland is a retrospective multicentre study that will include 450 patients with an operated glioblastoma, treated with any adjuvant therapy regimen in the UK and Ireland. Adult patients ≥18 years diagnosed with glioblastoma and undergoing surgery between 1 August 2018 and 1 February 2019 will be included. Clinical and radiological scanning data will be collected until the date of death or date of last known follow-up. Anonymised data will be uploaded to an online Castor database. Adherence to NICE guidelines and the effect of being concordant with NICE guidelines will be identified using descriptive statistics and Kaplan-Meier survival analysis.

Ethics and dissemination: Each participating centre is required to gain local institutional approval for data collection and sharing. Formal ethical approval is not required since this is a service evaluation. Results of the study will be reported through peer-reviewed presentations and articles, and will be disseminated to participating centres, patients and the public.

Keywords: NEUROSURGERY; Neurological oncology; Neuroradiology.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

**Figure 1**
Process of identifying a patient list at each collaborating neurosurgical unit. CNS, Central Nervous System; GB, Glioblastoma.

**Figure 2**
Bar chart representing pilot data compliance to NICE guidelines. NICE, National Institute for Health and Care Excellence.

See this image and copyright information in PMC

References

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Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study

Collaborators

Affiliations

Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical