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Comment
. 2023 Jan;48(1):9-10.
doi: 10.1016/j.tibs.2022.08.008. Epub 2022 Sep 10.

Snapshots of a tiny ancestral nuclease of Cas9

Zhonggang Hou  1 , Renke Tan  1 , Yan Zhang  2
Affiliations
Comment

Snapshots of a tiny ancestral nuclease of Cas9

Zhonggang Hou et al. Trends Biochem Sci. 2023 Jan.

Abstract

High-resolution structures solved by Schuler et al. shed light on how Cas9's evolutionary ancestor IscB operates as an RNA-guided nuclease. With only two-fifths the size of Cas9, IscB holds great promise for alleviating the cargo size constraint of in vivo CRISPR delivery.

Keywords: CRISPR; Cas9; IscB; RNA-guided nuclease; genome editing.

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Declaration of interests No interests are declared.

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