Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Sep;52(9):1478-1487.
doi: 10.1111/imj.15904.

Overview of recent advancements in asthma management

Ashleigh Witt  1 , Jo A Douglass  2 , Nur-Shirin Harun  1   2
Affiliations

Overview of recent advancements in asthma management

Ashleigh Witt et al. Intern Med J. 2022 Sep.

Abstract

Asthma is a common but complex heterogenous inflammatory airway disorder. Despite significant developments in our understanding of the pathophysiology and treatment of asthma, it remains a major cause of mortality and morbidity. Optimal management involves addressing modifiable risk factors, titration of inhaled pharmacotherapy in a stepwise approach and, in severe disease, consideration of biologic agents. Appreciation of the clinical characteristics of asthma and recognition of the immune pathways involved has allowed the development of phenotypic and endotypic subtypes of asthma to be better defined. This has revolutionised asthma management, allowing risk stratification of patients, targeted use of biologic agents to modify cytokine responses that drive asthma and improved patient outcomes. Patient education and engagement are critical to the management of this disease in an era of personalised medicine and a rapidly changing global environment.

Keywords: asthma; biologic treatments; management; personalised medicine.

PubMed Disclaimer

References

    1. Asthma Australia. Asthma Statistics and Facts. Available from URL: https://asthma.org.au/about-asthma/understanding-asthma/statistics
    1. GINA. Global Strategy for Asthma Management and Prevention. 2021. Available from URL: www.ginasthma.org
    1. Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G et al. After asthma: redefining airways diseases. Lancet 2018; 391: 350-400.
    1. Levy ML. The national review of asthma deaths: what did we learn and what needs to change? Breathe 2015; 11: 14-24.
    1. Global Asthma Report. 2018. Available from URL: http://globalasthmareport.org/