Trends in direct oral anticoagulant use in patients presenting with acute stroke
- PMID: 36100570
- PMCID: PMC9546077
- DOI: 10.1111/imj.15903
Trends in direct oral anticoagulant use in patients presenting with acute stroke
Abstract
Acute ischaemic strokes occur despite the use of direct oral anticoagulants (DOACs). A retrospective review was conducted at a high-volume primary stroke centre over a 3-year period to assess the acute management of stroke presentations in patients prescribed DOACs. During the time period of the study, 103 of 195 anticoagulated stroke patients presented within the timeframe for thrombolysis and only 15 patients had DOAC plasma level assays performed. Of these 103, 5 received thrombolysis; however, DOAC level was not a factor in these cases.
Keywords: DOAC level; direct oral anticoagulant; ischaemic; stroke; thrombolysis.
© 2022 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.
References
-
- van Walraven C, Hart R, Singer D, Laupacis A, Connolly S, Petersen P et al. Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation. JAMA 2002; 288: 2441. - PubMed
-
- Ntaios G, Papavasileiou V, Diener HC, Makaritsis K, Michel P. Nonvitamin‐K‐antagonist oral anticoagulants in patients with atrial fibrillation and previous stroke or transient ischemic attack: a systematic review and meta‐analysis of randomized controlled trials. Stroke 2012; 43: 3298–304. - PubMed
-
- Australian Commission on Safety and Quality in Health Care . Medication Without Harm – WHO Global Patient Safety Challenge. Australia's Response. Sydney: ACSQHC; 2020.
-
- Valente M, Leung S, Wu P, Oh D, Tran H, Choi P. Ischaemic stroke and transient ischaemic attack on anticoagulants: outcomes in the era of direct oral anticoagulants. Intern Med J 2020; 50: 110–13. - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical