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Comment
. 2024 Jan;29(1):3-4.
doi: 10.1038/s41380-022-01766-6. Epub 2022 Sep 13.

Comments to behavioral tests for antidepressant-like actions of (2R,6R)-hydroxynorketamine by Bonaventura et al

Lijia Chang  1 , Kenji Hashimoto  2
Affiliations
Comment

Comments to behavioral tests for antidepressant-like actions of (2R,6R)-hydroxynorketamine by Bonaventura et al

Lijia Chang et al. Mol Psychiatry. 2024 Jan.
No abstract available

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Comment on

  • Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search.
    Bonaventura J, Gomez JL, Carlton ML, Lam S, Sanchez-Soto M, Morris PJ, Moaddel R, Kang HJ, Zanos P, Gould TD, Thomas CJ, Sibley DR, Zarate CA Jr, Michaelides M. Bonaventura J, et al. Mol Psychiatry. 2022 Oct;27(10):4144-4156. doi: 10.1038/s41380-022-01673-w. Epub 2022 Jun 29. Mol Psychiatry. 2022. PMID: 35768639 Free PMC article.

References

    1. Hashimoto K. Ketamine: anesthetic, psychotomimetic, antidepressant, or anthelmintic? Mol Psychiatry. 2022. https://doi.org/10.1038/s41380-022-01587-7
    1. Hashimoto K. Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine. Biochem Pharmacol. 2020;177:113935. https://doi.org/10.1016/j.bcp.2020.113935 - DOI - PubMed
    1. Wei Y, Chang L, Hashimoto K. Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor. Mol Psychiatry. 2022;27:559–73. https://doi.org/10.1038/s41380-021-01121-1 - DOI - PubMed
    1. Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, et al. NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 2016;533:481–6. https://doi.org/10.1038/nature17998 - DOI - PubMed - PMC
    1. Yamaguchi JI, Toki H, Qu Y, Yang C, Koike H, Hashimoto K, et al. (2R,6R)-hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice. Neuropsychopharmacology 2018;43:1900–7. https://doi.org/10.1038/s41386-018-0084-y - DOI - PubMed - PMC

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