Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2023 Aug;192(4):1737-1743.
doi: 10.1007/s11845-022-03159-8. Epub 2022 Sep 13.

Comparison of intravenous ibuprofen and tenoxicam efficiency in ankle injury: a randomized, double-blind study

Gonca Koksaldi Sahin  1 , Muge Gulen  1 , Selen Acehan  1 , Deniz Aka Satar  2 , Tahsin Erfen  3 , Salim Satar  4
Affiliations
Randomized Controlled Trial

Comparison of intravenous ibuprofen and tenoxicam efficiency in ankle injury: a randomized, double-blind study

Gonca Koksaldi Sahin et al. Ir J Med Sci. 2023 Aug.

Abstract

Background and aim: Pain after soft tissue injuries in and around the ankle is a troublesome process in terms of patient comfort and mobilization. The aim of this study was to compare the analgesic efficacy of intravenous ibuprofen and intravenous tenoxicam in patients with acute musculoskeletal pain due to ankle injury.

Methods: We conducted a prospective, double-blind, randomized controlled study in a tertiary hospital. The patients were divided into two groups as those administered IV 400 mg ibuprofen and IV 20 mg tenoxicam. After the treatment of the patients, visual analog scale (VAS) scores were recorded at 15, 30, 60, and 120 min. VAS scores were compared with the effectiveness of drugs, their side effects, and the need for rescue drugs.

Results: One hundred and twenty-four patients were included in the study. There were 62 patients in the tenoxicam group and 62 patients in the ibuprofen group. When VAS scores were compared, it was found that the VAS scores of the ibuprofen group were statistically significantly lower (p < 0.001). When the ΔVAS scores were compared, it was observed that the ΔVAS scores of the ibuprofen group were statistically significantly higher from 30 min (p < 0.001). There was a statistically significant difference in favor of ibuprofen between the two drug groups in terms of the need for rescue analgesics (p < 0.001). Conclusıon. The analgesic efficacy of intravenous ibuprofen and tenoxicam is equal after an ankle injury. However, after 30 min of drug administration, ibuprofen provides more effective analgesia than tenoxicam.

Keywords: Ankle injury; Emergency; Ibuprofen; Pain; Tenoxicam.

PubMed Disclaimer

References

    1. Fathi M, Zare MA, Bahmani HR et al (2015) Comparison of oral oxycodone and naproxen in soft tissue injury pain control: a double-blind randomized clinical trial. Am J Emerg Med 33(9):1205–1208. https://doi.org/10.1016/j.ajem.2015.05.021 (PMID: 26166378) - DOI - PubMed
    1. Adamson C, Cymet T (1997) Ankle sprains: evaluation, treatment, rehabilitation. Md Med J 46(10):530–537 (PMID: 9392942) - PubMed
    1. Dizon JM, Reyes JJ (2010) A systematic review on the effectiveness of external ankle supports in the prevention of inversion ankle sprains among elite and recreational players. J Sci Med Sport 13(3):309–317. https://doi.org/10.1016/j.jsams.2009.05.002 - DOI - PubMed
    1. Martin RL, Davenport TE, Paulseth S et al (2013) Orthopaedic Section American Physical Therapy Association. Ankle stability and movement coordination impairments: ankle ligament sprains. J Orthop Sports Phys Ther 43(9):A1-40. https://doi.org/10.2519/jospt.2013.0305 - DOI - PubMed
    1. Sullivan WJ, Panagos A, Foye PM et al (2007) Industrial medicine and acute musculoskeletal rehabilitation. 2. Medications for the treatment of acute musculoskeletal pain. Arch Phys Med Rehabil 88(3 Supp 1):S10–S13. https://doi.org/10.1016/j.apmr.2006.12.009 - DOI - PubMed

Publication types

LinkOut - more resources