. 2022 Sep 13;23(1):311.

doi: 10.1186/s12882-022-02937-x.

Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study

Ian E McCoy¹, Jesse Y Hsu², Joseph V Bonventre³, Chirag R Parikh⁴, Alan S Go⁵, Kathleen D Liu⁶, Ana C Ricardo⁷, Anand Srivastava⁸, Debbie L Cohen⁹, Jiang He¹⁰, Jing Chen^{10

11}, Panduranga S Rao¹², Anthony N Muiru⁶, Chi-Yuan Hsu^{6

5}

Affiliations

¹ Division of Nephrology, University of California San Francisco, Box 0532, 500 Parnassus Ave., MUW418, 94143-0532, San Francisco, CA, USA. ian.mccoy@ucsf.edu.
² Division of Biostatistics, University of Pennsylvania, Philadelphia, PA, USA.
³ Division of Renal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
⁴ Division of Nephrology, Johns Hopkins University, Baltimore, MD, USA.
⁵ Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
⁶ Division of Nephrology, University of California San Francisco, Box 0532, 500 Parnassus Ave., MUW418, 94143-0532, San Francisco, CA, USA.
⁷ Division of Nephrology, University of Illinois, Chicago, IL, USA.
⁸ Division of Nephrology and Hypertension, Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
⁹ Division of Nephrology, University of Pennsylvania, Philadelphia, PA, USA.
¹⁰ Department of Epidemiology, Tulane University, New Orleans, Louisiana, USA.
¹¹ Division of Nephrology, Tulane University, New Orleans, Louisiana, USA.
¹² Division of Nephrology, University of Michigan, Ann Arbor, MI, USA.

PMID: 36100915
PMCID: PMC9472364
DOI: 10.1186/s12882-022-02937-x

Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study

Ian E McCoy et al. BMC Nephrol. 2022.

. 2022 Sep 13;23(1):311.

doi: 10.1186/s12882-022-02937-x.

Authors

Affiliations

¹ Division of Nephrology, University of California San Francisco, Box 0532, 500 Parnassus Ave., MUW418, 94143-0532, San Francisco, CA, USA. ian.mccoy@ucsf.edu.
² Division of Biostatistics, University of Pennsylvania, Philadelphia, PA, USA.
³ Division of Renal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
⁴ Division of Nephrology, Johns Hopkins University, Baltimore, MD, USA.
⁵ Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
⁶ Division of Nephrology, University of California San Francisco, Box 0532, 500 Parnassus Ave., MUW418, 94143-0532, San Francisco, CA, USA.
⁷ Division of Nephrology, University of Illinois, Chicago, IL, USA.
⁸ Division of Nephrology and Hypertension, Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
⁹ Division of Nephrology, University of Pennsylvania, Philadelphia, PA, USA.
¹⁰ Department of Epidemiology, Tulane University, New Orleans, Louisiana, USA.
¹¹ Division of Nephrology, Tulane University, New Orleans, Louisiana, USA.
¹² Division of Nephrology, University of Michigan, Ann Arbor, MI, USA.

PMID: 36100915
PMCID: PMC9472364
DOI: 10.1186/s12882-022-02937-x

Abstract

Background: Mechanisms by which AKI leads to CKD progression remain unclear. Several urine biomarkers have been identified as independent predictors of progressive CKD. It is unknown whether AKI may result in long-term changes in these urine biomarkers, which may mediate the effect of AKI on CKD progression.

Methods: We selected 198 episodes of hospitalized AKI (defined as peak/nadir inpatient serum creatinine values ≥ 1.5) among adult participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. We matched the best non-AKI hospitalization (unique patients) for each AKI hospitalization using pre-hospitalization characteristics including eGFR and urine protein/creatinine ratio. Biomarkers were measured in banked urine samples collected at annual CRIC study visits.

Results: Urine biomarker measurements occurred a median of 7 months before and 5 months after hospitalization. There were no significant differences in the change in urine biomarker-to-creatinine ratio between the AKI and non-AKI groups: KIM-1/Cr + 9% vs + 7%, MCP-1/Cr + 4% vs + 1%, YKL-40/Cr + 7% vs -20%, EGF/Cr -11% vs -8%, UMOD/Cr -2% vs -7% and albumin/Cr + 17% vs + 13% (all p > 0.05).

Conclusion: In this cohort of adults with CKD, AKI did not associate with long-term changes in urine biomarkers.

Keywords: Acute kidney injury; Biomarkers; Chronic kidney disease.

PubMed Disclaimer

Conflict of interest statement

None of the authors declare disclosures of direct relevance to the submitted work.

Figures

**Fig. 1**
Post-hospitalization changes in eGFR. Legend: Each faded line shows the eGFR measurements for an individual patient. The bright lines show non-parametric smooth eGFR trajectories for each group. P value from linear mixed effects model

See this image and copyright information in PMC

References

1. Susantitaphong P, Cruz DN, Cerda J, Abulfaraj M, Alqahtani F, Koulouridis I, et al. World incidence of AKI: A meta-analysis. Clin J Am Soc Nephrol. 2013;8(9):1482–1493. doi: 10.2215/CJN.00710113. - DOI - PMC - PubMed
1. Al-Jaghbeer M, Dealmeida D, Bilderback A, Ambrosino R, Kellum JA. Clinical Decision Support for In-Hospital AKI. J Am Soc Nephrol. 2018;29(2):654–660. doi: 10.1681/ASN.2017070765. - DOI - PMC - PubMed
1. Heung M, Steffick DE, Zivin K, Gillespie BW, Banerjee T, Hsu CY, et al. Acute Kidney Injury Recovery Pattern and Subsequent Risk of CKD: An Analysis of Veterans Health Administration Data. Am J Kidney Dis. 2016;67(5):742–752. doi: 10.1053/j.ajkd.2015.10.019. - DOI - PMC - PubMed
1. Hsu CY, Chertow GM, McCulloch CE, Fan D, Ordoñez JD, Go AS. Nonrecovery of kidney function and death after acute on chronic renal failure. Clin J Am Soc Nephrol. 2009;4(5):891–898. doi: 10.2215/CJN.05571008. - DOI - PMC - PubMed
1. Lo LJ, Go AS, Chertow GM, McCulloch CE, Fan D, Ordõez JD, et al. Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int. 2009;76(8):893–899. doi: 10.1038/ki.2009.289. - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study

Affiliations

Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous