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Review
. 2022 Aug;29(4):6-13.
doi: 10.21315/mjms2022.29.4.2. Epub 2022 Aug 29.

Antimicrobial Effects of Tetraspanins: A New Turnabout in Treatment of Microorganisms

Khairiyah Murad  1 , Sharaniza Ab Rahim  2 , Hassanain Al-Talib  3
Affiliations
Review

Antimicrobial Effects of Tetraspanins: A New Turnabout in Treatment of Microorganisms

Khairiyah Murad et al. Malays J Med Sci. 2022 Aug.

Abstract

Tetraspanins, a transmembrane protein is a 'molecular organiser' with diverse functions that promote a network of signalling involved in the cellular and pathological processes. Tetraspanins-enriched microdomains (TEMs) are the crucial feature for the protein-protein interactions in the cell membrane and are vulnerable to pathogens exploitation. Targetting the tetraspanins has shown to be effective against microbial infections although more research is needed to be performed. This article will review previous evidence that has successfully demonstrated the potential mechanism to target tetraspanins as an antimicrobial agent.

Keywords: antibodies; antimicrobial; bacterial adhesion; blocking peptide; tetraspanins.

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Conflict of interest statement

Conflict of Interest None.

Figures

Figure 1
Figure 1
The CD9 (representative) (a) overall structure of the tetraspanins, (b) surface expression of the tetraspanins and (c) location of palmitoylation at the cysteine residues (11)
See this image and copyright information in PMC

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