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. 2022;8(1):47.
doi: 10.1186/s41100-022-00434-3. Epub 2022 Sep 8.

Activity of daily life dependency predicts the risk of mortality in patients with COVID-19 undergoing hemodialysis: a retrospective analysis of a single center with nosocomial outbreak

Jun Ino  1 , Fumika Iemura  1 , Chihiro Nakajima  1 , Mio Kodama  1 , Saeko Kumon  1 , Keitaro Sato  1 , Hitoshi Eizumi  1 , Nobuhiro Hijikata  2 , Sadayuki Oshio  3 , Shingo Tachibana  4 , Kosaku Nitta  5 , Junichi Hoshino  5
Affiliations

Activity of daily life dependency predicts the risk of mortality in patients with COVID-19 undergoing hemodialysis: a retrospective analysis of a single center with nosocomial outbreak

Jun Ino et al. Ren Replace Ther. 2022.

Abstract

Background: We experienced a nosocomial outbreak of coronavirus disease 2019 (COVID-19) from November 2020 to February 2021, during the third wave of the pandemic in Japan.

Methods: We retrospectively assessed the characteristics and data of 20 inpatients undergoing hemodialysis who were hospitalized for treatment of diseases other than COVID-19 during the COVID-19 nosocomial outbreak ("inpatient," IP), and of 10 outpatients undergoing hemodialysis who were hospitalized for the care of COVID-19 under outpatient visits ("outpatient," OP).

Results: Eleven patients in the IP group (55%) and one in the OP group (10%) died. Kaplan-Meier analysis showed that the IP group died more rapidly than the OP group (p = 0.02). Multivariate analysis among all hemodialysis patients showed that the IP group was not at risk of mortality independently; however, the activity of daily life (ADL) dependency was found to be an independent factor in increasing the risk of mortality (hazard ratio: 7.618).

Conclusion: Our findings show that the nosocomial infected group has a worse prognosis, although it is not an independent predictor for the risk of mortality. ADL dependency could predict the risk of mortality in all hemodialysis patients with COVID-19 during the third wave pandemic in Japan.

Keywords: Activities of daily life dependency; COVID-19; Hemodialysis; Nosocomial outbreak.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of the patient selection process and main outcomes. COVID-19, coronavirus disease 2019
Fig. 2
Fig. 2
Survival analysis using Kaplan–Meier survival curves. We used Kaplan–Meier survival curves to analyze outcomes of inpatients and outpatients during the hospitalization period. We assessed the occurrence rates of the a one-step progression of severity, b development to severe grade, and c death during the entire hospitalization. We performed a Log-rank test, and differences were considered significant when p < 0.05. IP, inpatient group; OP, outpatient group
See this image and copyright information in PMC

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