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. 2022 Nov;117(11):1279-1286.
doi: 10.1111/vox.13357. Epub 2022 Sep 14.

Use of O RhD-negative red blood cells: A nationwide, prospective audit

Minna Ilmakunnas  1   2 , Katja Salmela  2 , Tiia Kivipuro  3 , Hannele Sareneva  3 , Susanna Sainio  3
Affiliations

Use of O RhD-negative red blood cells: A nationwide, prospective audit

Minna Ilmakunnas et al. Vox Sang. 2022 Nov.

Abstract

Background and objectives: Despite declining transfusion rates, overuse of O RhD-negative red blood cells (RBCs) risks the secure supply of this limited resource. A nationwide prospective audit was performed in Finland to understand the clinical use and inventory management of O RhD-negative units. Our aim was to identify areas where policy changes could help alleviate the shortage of O RhD-negative RBCs.

Materials and methods: The use of every O RhD-negative unit in Finland during a period of 1 month was reviewed. For each issued unit (n = 1105), unit age, urgency of transfusion, hospital and patient demographics, and specific reasons for issuing O RhD-negative units were recorded.

Results: Almost half of the O RhD-negative units (n = 529, 47.9%) were issued to non-O RhD-negative patients. Only 22.3% (n = 118) were issued for females under the age of 50. Of the units for ABO-nonidentical transfusion, one-third (32.5%, n = 172) were issued for emergency transfusion, two-thirds (67.5%, n = 357) for non-urgent transfusions. The most common reason for issuing an O RhD-negative unit was inventory management (n = 172, 48.2% of units issued for non-urgent transfusion). Most of these units were issued close to the unit expiry date.

Conclusion: This nationwide audit revealed that a significant proportion of O RhD-negative RBCs are used inappropriately. Clinicians should be educated on the appropriate use of O RhD-negative RBCs, and blood banks should develop strategies for inventory management to avoid issuing O RhD-negative units purely to prevent outdating.

Keywords: O RhD-negative; emergency transfusion; inventory management; red cell components.

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References

REFERENCES

    1. Beckman N, Yazer M, Land K, Chesneau S, Caulfield J. Blood banks meet the paradox of Gabriel's Horn: what are the options to maintain supply as demand decreases? Transfus Med. 2016;26:170-6.
    1. Barty RL, Pai M, Liu Y, Arnold DM, Cook RJ, Zeller MP, et al. Group O RBCs: where is universal donor blood being used. Vox Sang. 2017;112:336-42.
    1. Hirani R, Wong J, Diaz P, Mondy P, Hogan C, Dennington PM, et al. A national review of the clinical use of group O D− red blood cell units. Transfusion. 2017;57:1254-61.
    1. Murphy M, BenAvram D. Recommendations on the use of group O RBCs. AABB Association Bulletin #19-02. Accessed March 15, 2022. https://www.aabb.org/programs/publications/bulletins/Documents/ab19-02.pdf
    1. Virk MS, Lancaster D, Quach T, Lim A, Shu E, Belanger G, et al. Optimizing O-negative RBC utilization using a data-driven approach. Transfusion. 2020;60:739-46.

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