ETV4 immunohistostaining is a sensitive and specific diagnostic biomarker for CIC-rearranged sarcoma of the central nervous system

Chloé Ouvrard¹, Alice Métais^{1

2

3}, Enola Brigot¹, Charlotte Berthaud¹, Noémie Pucelle¹, Joëlle Lacombe¹, Lauren Hasty¹, Fabrice Chrétien^{1

2}, Franck Bielle⁴, Karima Mokhtari⁴, Dominique Cazals-Hatem⁵, Benoît Lhermitte⁶, Emmanuelle Uro-Coste^{7

8

9}, Pascale Varlet^{1

2

3}, Arnault Tauziède-Espariat^{1

2

3}; RENOCLIP-LOC

Affiliations

¹ Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France.
² Université de Paris, Paris, France.
³ Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR S1266, INSERM, IMA-BRAIN, Paris, France.
⁴ ICM, Inserm, CNRS, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neuropathologie, F-75013, Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute, Paris, France.
⁵ Department of Pathology, APHP University Hospital Beaujon, Clichy, France.
⁶ Department of Pathology, Strasbourg Hospital, Strasbourg, France.
⁷ Department of Pathology, Toulouse University Hospital, Toulouse, France.
⁸ INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
⁹ Université Paul Sabatier, Toulouse, France.

Chloé Ouvrard et al. Histopathology. 2022 Dec.

. 2022 Dec;81(6):852-855.

doi: 10.1111/his.14796. Epub 2022 Oct 4.

¹ Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France.
² Université de Paris, Paris, France.
³ Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR S1266, INSERM, IMA-BRAIN, Paris, France.
⁴ ICM, Inserm, CNRS, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neuropathologie, F-75013, Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute, Paris, France.
⁵ Department of Pathology, APHP University Hospital Beaujon, Clichy, France.
⁶ Department of Pathology, Strasbourg Hospital, Strasbourg, France.
⁷ Department of Pathology, Toulouse University Hospital, Toulouse, France.
⁸ INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
⁹ Université Paul Sabatier, Toulouse, France.

No abstract available

References

1. Louis DN, Perry A, Wesseling P et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncol 2021; 23; 1231-1251.
1. Pratt D, Kumar-Sinha C, Cieślik M et al. A novel ATXN1-DUX4 fusion expands the spectrum of ‘CIC-rearranged sarcoma’ of the CNS to include non-CIC alterations. Acta Neuropathol. (Berl.) 2021; 141; 619-622.
1. Siegfried A, Masliah-Planchon J, Roux F-E et al. Brain tumor with an ATXN1-NUTM1 fusion gene expands the histologic spectrum of NUTM1-rearranged neoplasia. Acta Neuropathol. Commun. 2019; 7; 220.
1. Le Guellec S, Velasco V, Pérot G et al. ETV4 is a useful marker for the diagnosis of CIC-rearranged undifferentiated round-cell sarcomas: a study of 127 cases including mimicking lesions. Mod. Pathol. Off. J. U. S. Can. Acad. Pathol. Inc 2016; 29; 1523-1531.
1. Hung YP, Fletcher CD, Hornick JL. Evaluation of ETV4 and WT1 expression in CIC-rearranged sarcomas and histologic mimics. Mod. Pathol. Off. J. U. S. Can. Acad. Pathol. Inc 2016; 29; 1324-1334.