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Review
. 2022 Dec;59(12):7152-7169.
doi: 10.1007/s12035-022-03028-6. Epub 2022 Sep 14.

The Neuroprotection Effects of Exosome in Central Nervous System Injuries: a New Target for Therapeutic Intervention

Li Zhang  1 , Lei Mao  1 , Handong Wang  2
Affiliations
Review

The Neuroprotection Effects of Exosome in Central Nervous System Injuries: a New Target for Therapeutic Intervention

Li Zhang et al. Mol Neurobiol. 2022 Dec.

Abstract

Central nervous system (CNS) injuries, including traumatic brain injury (TBI), spinal cord injury (SCI), and subarachnoid hemorrhage (SAH), are the most common cause of death and disability around the world. As a key subset of extracellular vesicles (EVs), exosomes have recently attracted great attentions due to their functions in remodeling extracellular matrix and transmitting signals and molecules. A large number of studies have suggested that exosomes played an important role in brain development and involved in many neurological disorders, particularly in CNS injuries. It has been proposed that exosomes could improve cognition function, inhibit apoptosis, suppress inflammation, regulate autophagy, and protect blood brain barrier (BBB) in CNS injuries via different molecules and pathways including microRNA (miRNA), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT), Notch1, and extracellular regulated protein kinases (ERK). Therefore, exosomes showed great promise as potential targets in CNS injuries. In this article, we present a review highlighting the applications of exosomes in CNS injuries. Hence, on the basis of these properties and effects, exosomes may be developed as therapeutic agents for CNS injury patients.

Keywords: Central nervous system injuries; Downstream molecules; Exosomes.

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References

    1. Hornby TG, Reisman DS, Ward IG, Scheets PL, Miller A, Haddad D, Fox EJ, Fritz NE et al (2020) Clinical practice guideline to improve locomotor function following chronic stroke, incomplete spinal cord injury, and brain injury. J Neurol Phys Ther 44(1):49–100. https://doi.org/10.1097/NPT.0000000000000303 - DOI - PubMed
    1. Zhang L, Wang H (2019) Long non-coding RNA in CNS injuries: a new target for therapeutic intervention. Mol Ther Nucl Acids 17:754–766. https://doi.org/10.1016/j.omtn.2019.07.013 - DOI
    1. Devanney NA, Stewart AN, Gensel JC (2020) Microglia and macrophage metabolism in CNS injury and disease: the role of immunometabolism in neurodegeneration and neurotrauma. Exp Neurol 329:113310. https://doi.org/10.1016/j.expneurol.2020.113310 - DOI - PubMed - PMC
    1. Liddelow SA, Barres BA (2017) Reactive astrocytes: production, function, and therapeutic potential. Immunity 46(6):957–967. https://doi.org/10.1016/j.immuni.2017.06.006 - DOI - PubMed
    1. Hill AF (2019) Extracellular vesicles and neurodegenerative diseases. J Neurosci 39(47):9269–9273. https://doi.org/10.1523/JNEUROSCI.0147-18.2019 - DOI - PubMed - PMC

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