Resistance to Paracoccidioides brasiliensis in mice is controlled by a single dominant autosomal gene
- PMID: 3610318
- PMCID: PMC260625
- DOI: 10.1128/iai.55.8.1919-1923.1987
Resistance to Paracoccidioides brasiliensis in mice is controlled by a single dominant autosomal gene
Abstract
In a previous report it was shown that there are resistant, susceptible, and intermediate strains of mice to intraperitoneal Paracoccidioides brasiliensis infection. In the present work, we investigated the type of inheritance and the number of genes that determine resistance to paracoccidioidomycosis. Parental and hybrid mice were inoculated intraperitoneally with 5 X 10(6) P. brasiliensis yeast cells, and mortality was scored daily. Analysis of susceptible and resistant parental strains and of F1, F2, and backcross mice showed that the resistance to P. brasiliensis seems to be controlled genetically by a single dominant gene, which we designated the Pbr locus. The mean survival times of susceptible F2 and backcross hybrids were very similar to that of the susceptible parent. Examination of the pathological changes observed in parental and F1 mice, 6 months after infection, showed that F1 offspring presented a similar number and distribution of lesions to those of the resistant strains. The Pbr gene is not linked to H-2, Hc, and albino genes. Furthermore, resistance to paracoccidioidomycosis is controlled by an autosomal gene.
Similar articles
-
Innate immunity to Paracoccidioides brasiliensis infection.Mycopathologia. 2008 Apr-May;165(4-5):223-36. doi: 10.1007/s11046-007-9048-1. Mycopathologia. 2008. PMID: 18777631 Review.
-
Experimental paracoccidioidomycosis: early immunosuppression occurs in susceptible mice after infection with pathogenic fungi.Braz J Med Biol Res. 1987;20(5):587-9. Braz J Med Biol Res. 1987. PMID: 3452450
-
Influence of the genetic background on the pattern of lesions developed by resistant and susceptible mice infected with Paracoccidioides brasiliensis.Med Microbiol Immunol. 1999 Aug;188(1):41-9. doi: 10.1007/s004300050103. Med Microbiol Immunol. 1999. PMID: 10691092
-
Effect of macrophage blockade on the resistance of inbred mice to Paracoccidioides brasiliensis infection.Mycopathologia. 1995 Jun;130(3):131-40. doi: 10.1007/BF01103095. Mycopathologia. 1995. PMID: 7566066
-
Immune response to Paracoccidioides brasiliensis in human and animal hosts.Curr Top Med Mycol. 1988;2:239-77. doi: 10.1007/978-1-4612-3730-3_7. Curr Top Med Mycol. 1988. PMID: 3288357 Review. No abstract available.
Cited by
-
Delayed-type hypersensitivity response in an isogenic murine model of paracoccidioidomycosis.Mycopathologia. 1994 Jun;126(3):137-46. doi: 10.1007/BF01103767. Mycopathologia. 1994. PMID: 7935728
-
Polymorphism in the Promoter Region of the IL18 Gene and the Association With Severity on Paracoccidioidomycosis.Front Immunol. 2020 Oct 1;11:542210. doi: 10.3389/fimmu.2020.542210. eCollection 2020. Front Immunol. 2020. PMID: 33117339 Free PMC article. Clinical Trial.
-
Studies on the relationship between paracoccidioidomycosis in ddY mice and their estrous cycle.Mycopathologia. 1991 Aug;115(2):73-81. doi: 10.1007/BF00436795. Mycopathologia. 1991. PMID: 1784309
-
Innate immunity to Paracoccidioides brasiliensis infection.Mycopathologia. 2008 Apr-May;165(4-5):223-36. doi: 10.1007/s11046-007-9048-1. Mycopathologia. 2008. PMID: 18777631 Review.
-
Pathogenicity of Saccharomyces cerevisiae in complement factor five-deficient mice.Infect Immun. 1995 Feb;63(2):478-85. doi: 10.1128/iai.63.2.478-485.1995. Infect Immun. 1995. PMID: 7822013 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous