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Comment
. 2022 Sep 13;55(9):1583-1585.
doi: 10.1016/j.immuni.2022.08.012.

Skip the buffet, for SPARC's sake

Lukai Zhai  1 , Connie M Krawczyk  2
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Skip the buffet, for SPARC's sake

Lukai Zhai et al. Immunity. .
Free article

Abstract

Caloric restriction (CR) reduces inflammation and the incidence of chronic diseases, thereby extending healthspan and lifespan. In this issue of Immunity, Ryu et al. (2022) propose that reduction of SPARC, a matricellular protein, during CR offers beneficial effects by reducing SPARC-driven inflammatory phenotypes in macrophages.

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Conflict of interest statement

Declaration of interests C.M.K. is an adjunct professor at McGill University, Canada.

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