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Comment
. 2022 Sep 13;55(9):1586-1588.
doi: 10.1016/j.immuni.2022.08.014.

The best offense is a good beta-defensin

Miqdad O Dhariwala  1 , Tiffany C Scharschmidt  2
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The best offense is a good beta-defensin

Miqdad O Dhariwala et al. Immunity. .
Free article

Abstract

The full range of receptors through which antimicrobial peptides exert their immunologic effects remains incompletely explored. Dong and colleagues identify Mgrpra2 as a G-coupled protein receptor on neutrophils, for which keratinocyte-derived Beta-defensins serve as key ligands. Binding of Mgrpra2 leads to release of neutrophil granules and Il-1β, which helps shape skin microbiome composition and augments cutaneous defense against bacterial infection.

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Conflict of interest statement

Declaration of interests T.C.S. is a scientific advisory board member for Concerto Biosciences.

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