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. 2022 Sep 14;12(9):e063813.
doi: 10.1136/bmjopen-2022-063813.

Diagnostic work-up of urinary tract infections in pregnancy: study protocol of a prospective cohort study

Dominique Esmée Werter  1 , Brenda M Kazemier  2 , Elisabeth van Leeuwen  3 , Maurits C F J de Rotte  4 , Sacha D Kuil  5 , Eva Pajkrt  6 , Caroline Schneeberger  7   8
Affiliations

Diagnostic work-up of urinary tract infections in pregnancy: study protocol of a prospective cohort study

Dominique Esmée Werter et al. BMJ Open. .

Abstract

Introduction: Symptoms of urinary tract infections in pregnant women are often less specific, in contrast to non-pregnant women where typical clinical symptoms of a urinary tract infection are sufficient to diagnose urinary tract infections. Moreover, symptoms of a urinary tract infection can mimic pregnancy-related symptoms, or symptoms of a threatened preterm birth, such as contractions. In order to diagnose or rule out a urinary tract infection, additional diagnostic testing is required.The diagnostic accuracy of urine dipstick analysis and urine sediment in the diagnosis of urinary tract infections in pregnant women has not been ascertained nor validated.

Methods and analysis: In this single-centre prospective cohort study, pregnant women (≥16 years old) with a suspected urinary tract infection will be included. The women will be asked to complete a short questionnaire regarding complaints, risk factors for urinary tract infections and baseline characteristics. Their urine will be tested with a urine dipstick, urine sediment and urine culture. The different sensitivities and specificities per test will be assessed. Our aim is to evaluate and compare the diagnostic accuracy of urine dipstick analysis and urine sediment in comparison with urine culture (reference test) in pregnant women. In addition, we will compare these tests to a predefined 'true urinary tract infection', to distinguish between a urinary tract infection and asymptomatic bacteriuria.

Ethics and dissemination: Approval was requested from the Medical Ethics Review Committee of the Academic Medical Centre; an official approval of this study by the committee was not required. The outcomes of this study will be published in a peer-reviewed journal.

Keywords: BACTERIOLOGY; Maternal medicine; Microbiology; Protocols & guidelines; Urinary tract infections.

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Conflict of interest statement

Competing interests: None declared.

References

    1. Amiri M, Lavasani Z, Norouzirad R, et al. . Prevalence of Urinary Tract Infection Among Pregnant Women and its Complications in Their Newborns During the Birth in the Hospitals of Dezful City, Iran, 2012 - 2013. Iran Red Crescent Med J 2015;17:e26946. 10.5812/ircmj.26946 - DOI - PMC - PubMed
    1. Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med 2002;113 Suppl 1A:5–13. 10.1016/S0002-9343(02)01054-9 - DOI - PubMed
    1. Mazor-Dray E, Levy A, Schlaeffer F, et al. . Maternal urinary tract infection: is it independently associated with adverse pregnancy outcome? J Matern Fetal Neonatal Med 2009;22:124–8. 10.1080/14767050802488246 - DOI - PubMed
    1. Schieve LA, Handler A, Hershow R, et al. . Urinary tract infection during pregnancy: its association with maternal morbidity and perinatal outcome. Am J Public Health 1994;84:405–10. 10.2105/AJPH.84.3.405 - DOI - PMC - PubMed
    1. Schneeberger C, Erwich JJHM, van den Heuvel ER, et al. . Asymptomatic bacteriuria and urinary tract infection in pregnant women with and without diabetes: cohort study. Eur J Obstet Gynecol Reprod Biol 2018;222:176–81. 10.1016/j.ejogrb.2017.12.013 - DOI - PubMed