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Case Reports
. 2022 Nov;28(11):2336-2338.
doi: 10.3201/eid2811.221215. Epub 2022 Sep 14.

Monkeypox in Patient Immunized with ACAM2000 Smallpox Vaccine During 2022 Outbreak

Matthew Turner, Jeremy Mandia, Case Keltner, Robert Haynes, Paul Faestel, Luke Mease
Case Reports

Monkeypox in Patient Immunized with ACAM2000 Smallpox Vaccine During 2022 Outbreak

Matthew Turner et al. Emerg Infect Dis. 2022 Nov.

Abstract

We report a case of monkeypox in the United States in a patient who had been vaccinated with ACAM2000 smallpox vaccine 8 years earlier. Despite his vaccination status, he still contracted disease. He showed prodromal symptoms preceding development of painless penile lesions that later coalesced.

Keywords: ACAM200 smallpox vaccine; United States; acute infection; immunization; men who have sex with men; monkeypox; monkeypox virus; sexually transmitted infections; vaccination; vaccine-preventable diseases; vaccines; viruses.

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Figures

Figure
Figure
Evolution of penile lesions in patient who had monkeypox and was immunized with ACAM2000 smallpox vaccine during 2022 monkeypox outbreak, United States. A) Two days after constitutional symptoms developed; B) evolution of rash showing coalescence and development of a pustular appearance 6 days after onset of constitutional symptoms; C) ulceration of lesion on day 16; D) dissipation of lesion without residual scarring.
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