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. 2022 Nov;44(11):e2200086.
doi: 10.1002/bies.202200086. Epub 2022 Sep 14.

Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases

Alessandra Bigi  1 , Roberta Cascella  1 , Fabrizio Chiti  1 , Cristina Cecchi  1
Affiliations

Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases

Alessandra Bigi et al. Bioessays. 2022 Nov.

Abstract

Amyloid fibril formation plays a central role in the pathogenesis of a number of neurodegenerative diseases, including Alzheimer and Parkinson diseases. Transient prefibrillar oligomers forming during the aggregation process, exhibiting a small size and a large hydrophobic surface, can aberrantly interact with a number of molecular targets on neurons, including the lipid bilayer of plasma membranes, resulting in a fatal outcome for the cells. By contrast, the mature fibrils, despite presenting generally a high hydrophobic surface, are endowed with a low diffusion rate and poorly penetrate the interior of the lipid bilayer. However, increasing evidence shows that both intracellular α-synuclein fibrils, as well and as extracellular amyloid-β and β2-microglobulin fibrils, can release oligomers over time that quickly diffuse to reach the membrane of the neighboring cells. The persistent leakage of harmful oligomers from fibrils triggers an ongoing cascade of events resulting in a sustained injury to neurons and glia and also provides aggregates with the ability to cross biological membranes and diffuse between cells or cellular compartments.

Keywords: AD; PD; amyloid-β peptide; neurodegeneration; protein misfolding; toxic oligomers; α-synuclein.

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References

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