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. 2022 Sep 15;6(1):18.
doi: 10.1186/s41824-022-00137-2.

Foreign body-type giant cell reaction with extensive granulation tissue and intense inflammation after chemotherapy mimicking residual lymphoma on FDG PET

Sakib Kazi  1 , Stavros Raptis  2 , Farzad Abbaspour  3 , Wanzhen Zeng  4   5
Affiliations

Foreign body-type giant cell reaction with extensive granulation tissue and intense inflammation after chemotherapy mimicking residual lymphoma on FDG PET

Sakib Kazi et al. Eur J Hybrid Imaging. .

Abstract

Foreign body-type giant cell reaction is typically a biological and immunological reaction to the presence of foreign bodies such as catheters, parasites or biomaterials with a collection of fused macrophages (giant cell). We reported an unusual case of [18F]FDG PET findings in diffuse large B cell lymphoma in the urinary bladder following incomplete resection and chemotherapy. As the restaging [18F]FDG PET showed intense [18F]FDG uptake in the urinary bladder at the resection site concerning for recurrence, the lesion was subsequently resected and histopathology showed extensive granulation tissue with foreign body-type giant cell reaction with no suspected foreign bodies or neoplasia.

Keywords: Diffuse large B cell lymphoma; Foreign body-type giant cell reaction; [18F]FDG PET.

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Conflict of interest statement

The authors declare that there are no competing interests.

Figures

Fig. 1
Fig. 1
Fused transaxial images of FDG PET/CT with intense FDG uptake in the left lateral urinary bladder wall (SUVmax = 67.9) and calcification, at the prior resected and treated DLBCL
Fig. 2
Fig. 2
T2-weighted MRI images showed nonspecific irregular thickening of the left lateral bladder wall (arrows)
Fig. 3
Fig. 3
Fused PET and MRI, using bone as the landmark
Fig. 4
Fig. 4
Hematoxylin and eosin stain at 400× magnification with extensive vascularization and foreign body-type giant cell reaction
See this image and copyright information in PMC

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