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Review
. 2022 Sep 14;27(1):177.
doi: 10.1186/s40001-022-00805-w.

Critical illness and bone metabolism: where are we now and what is next?

Yun Cai  1 , Fuxin Kang  1 , Xiaozhi Wang  2
Affiliations
Review

Critical illness and bone metabolism: where are we now and what is next?

Yun Cai et al. Eur J Med Res. .

Abstract

Critical illness refers to the clinical signs of severe, variable and life-threatening critical conditions, often accompanied by insufficiency or failure of one or more organs. Bone health of critically ill patients is severely affected during and after ICU admission. Therefore, clinical work should focus on ICU-related bone loss, and early development and implementation of related prevention and treatment strategies: optimized and personalized nutritional support (high-quality protein, trace elements and intestinal prebiotics) and appropriate physiotherapy and muscle training should be implemented as early as possible after ICU admission and discharge. At the same time, the drug regulates excessive metabolism and resists osteoporosis.

Keywords: Bone metabolism; Critical illness; Nutritional support; Osteoporosis; Rehabilitation training.

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Conflict of interest statement

Authors have no competing financial or non-financial interests for current work.

Figures

Fig. 1
Fig. 1
Interaction of bone hyper-resorption and critical illness
Fig. 2
Fig. 2
Wnt/β-catenin signaling and diseases
Fig. 3
Fig. 3
Interaction between the OPG/RANK/RANKL pathway, inflammation and immune response
Fig. 4
Fig. 4
Interaction between the estrogen–endocrine pathway, the OPG/RANK/RANKL pathway and the Wnt/β-catenin signaling
See this image and copyright information in PMC

References

    1. Goossens C, Marques MB, Derde S, Vander Perre S, Dufour T, Thiessen SE, Guiza F, Janssens T, Hermans G, Vanhorebeek I, et al. Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness. J Cachexia Sarcopenia Muscle. 2017;8(1):89–101. doi: 10.1002/jcsm.12131. - DOI - PMC - PubMed
    1. Benz F, Roy S, Trautwein C, Roderburg C, Luedde T. Circulating microRNAs as biomarkers for sepsis. Int J Mol Sci. 2016;17(1):78. doi: 10.3390/ijms17010078. - DOI - PMC - PubMed
    1. Yang F, Fang F. Research progress in diagnosis and evaluation of intensive care unit-acquired weakness. Int J Mol Sci. 2021;33(12):1533–1536. - PubMed
    1. Lee P, Nair P, Eisman JA, Center JR. Bone failure in critical illness. Crit Care Med. 2016;44(12):2270–2274. doi: 10.1097/CCM.0000000000001874. - DOI - PubMed
    1. Rousseau AF, Kerschan-Schindl K, Scherkl M, Amrein K. Bone metabolism and fracture risk during and after critical illness. Curr Opin Crit Care. 2020;26(4):379–385. - PubMed