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Review
. 2022;8(6):409-417.
doi: 10.1007/s40495-022-00303-x. Epub 2022 Sep 9.

Green Synthesis-Mediated Nanoparticles and Their Curative Character Against Post COVID-19 Skin Diseases

Nivedhitha Kabeerdass  1 , Selvankumar Thangaswamy  2 , Vaithilingam Mohanasrinivasan  3 , Chandrasekaran Rajasekaran  3 , Selvakumar Sundaram  4 , Thajuddin Nooruddin  5 , Maghimaa Mathanmohun  1
Affiliations
Review

Green Synthesis-Mediated Nanoparticles and Their Curative Character Against Post COVID-19 Skin Diseases

Nivedhitha Kabeerdass et al. Curr Pharmacol Rep. 2022.

Abstract

Purpose of review: This article provides the explanatory manuscript regarding the SARS-Corona virus 2. Sub-titled as the history of single-stranded RNA, internal characters of COVID-19, resource, the life cycle of COVID-19, reservoir of the disease, secondary infections of COVID-19 and nano herbal remedy.

Recent findings: The skin is not the main target of the SARS-corona virus 2 infections but somehow directly or indirectly, it causes exacerbating eruptions on the skin. Recent research shows that curcumin-mediated synthesized AgNPs show its potential character in the entry of respiratory syncytial virus (RSV), blocks interaction with the viral surface, and damages the viral protein. In modern days, molecular docking studies fabricated copper iodide flower extract (CuI-FE) which shows tough inhibitory action against COVID-19. Many articles show green synthesis-mediated nanoparticles like silver, gold, zinc, copper, iron, titanium dioxide, selenium, and cadmium which possess high anti-viricidal activity.

Summary: The anti-oxidant, anti-viral, anti-inflammatory, anti-hive rich plant-mediated nanoparticle synthesis might be an alternative betterment, cost-effective, and eco-friendly medication for the skin disease caused by SARS-corona virus 2 (the viral clinical signs are itchy, hives, rashes, papules, psoriasis, and inflammation) and (non-viral clinical signs-pressure urticaria, contact dermatitis, and acne) that occurred as the result of COVID-19.

Keywords: Anti-hives; Coronavirus; Cuticular; Pandemic; Phytotherapeutic; Reservoir.

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Conflict of interest statement

Conflict of InterestThe authors declare no conflict of interest. Human and Animal Rights and Informed Consent. This article does not contain any studies with human or animal subjects performed by any of the authors.

Figures

Fig. 1
Fig. 1
Lifecycle of SARS-COV-2 and inhibition of skin infections by plant-mediated nanoparticles might act as an antiviral agent. (1) SARS-COV-2 virus. (2) ACE2 receptor (angiotensin-converting enzyme-2). (3) Pre inflammatory occurred due to ACE2 receptor. (4) Binding of the virus with ACE2 receptor. (5) mRNA synthesis of the viral genome. (6) Transcription and translation occur in the nucleus by the formation of virions in the endoplasmic reticulum, Golgi bodies, and mitochondria. (7) Assembly and budding of virions. (8) Exocytosis release of the mature viral progeny. (9) Plant-mediated metal nanoparticle (viral inhibitor). (10) Block the ACE2receptor and inhibit the virus entry by binding with the virus. (11) Block the transcription and translation, inhibit the formation of the virion in the cell organelles, and also inhibit the assembly of the virion. (12) Metal nanoparticles after playing the role of inhibitors and act as an anti-inflammatory agent. (13) Plant-mediated metal nanoparticles might act as an alternative medication in treating the skin infections caused by COVID-19
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