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Review
. 2022 Aug 29:13:976289.
doi: 10.3389/fimmu.2022.976289. eCollection 2022.

Advances in the study of HLA class Ib in maternal-fetal immune tolerance

Yiran Yang  1 , Wanning Wang  1 , Jing Weng  2 , Huifang Li  3 , Yanmin Ma  4 , Lingyan Liu  1 , Wei Ma  2
Affiliations
Review

Advances in the study of HLA class Ib in maternal-fetal immune tolerance

Yiran Yang et al. Front Immunol. .

Abstract

The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction.

Keywords: HLA class Ib; HLA-G, HLA-E, HLA-F; decidual immune cells; maternal-fetal immune tolerance; pregnancy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The difference among HLA class Ib.
Figure 2
Figure 2
Roles of HLA class Ib molecules in immune cells in maternal decidua.
See this image and copyright information in PMC

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