Review of Impact of COVID-19 on Maternal, Neonatal Outcomes, and Placental Changes

doi:10.7759/cureus.28631

Review

. 2022 Aug 31;14(8):e28631.

doi: 10.7759/cureus.28631. eCollection 2022 Aug.

Review of Impact of COVID-19 on Maternal, Neonatal Outcomes, and Placental Changes

Resham Tanna¹, Henry J Nava Dugarte², Sowjanya Kurakula^{3

4

5

6}, Vandana Muralidharan⁷, Arghadip Das⁸, Sri Padma Ravali Kanigalpula⁹, Ileana Elita Mendez¹⁰, Munaza Afaq¹¹, Radhika Bassi¹², Kinjal Shah¹³, Zainab Saddiq¹⁴

Affiliations

¹ Obstetrics and Gynaecology, Spartan Health Sciences University, Vieux Fort, LCA.
² Obstetrics and Gynaecology, Rejuvenating Fertility Centre, New York, USA.
³ Obstetrics and Gynecology, Mamta Institute of Medical Sciences, Khammam, IND.
⁴ Obstetrics and Gynecology, Sekgoma Memorial Hospital, Serowe, BWA.
⁵ Obstetrics and Gynecology, Nyangabgwe Referral Hospital, Francistown, BWA.
⁶ Obstetrics and Gynecology, Gandhi Medical College, Musheerabad, IND.
⁷ Obstetrics and Gynaecology, Lifeline Medical Associates, New Jersey, USA.
⁸ Internal Medicine, Nilratan Sircar Medical College and Hospital, Kolkata, IND.
⁹ Obstetrics and Gynaecology, Ascension Health via Christi Hospital, Manhattan, USA.
¹⁰ Medical Sciences Department, Universidad Autonoma de Centro America (UACA), San José, CRI.
¹¹ Obstetrics and Gynaecology, Government Medical College Srinagar, Srinagar, IND.
¹² Obstetrics and Gynaecology, Ross University School of Medicine, Bridgetown, BRB.
¹³ Health Administration, Edward J. Bloustein School of Planning and Public Policy, New Jersey, USA.
¹⁴ Obstetrics and Gynecology, Annotto Bay Hospital, St.Mary, JAM.

PMID: 36106265
PMCID: PMC9450993
DOI: 10.7759/cureus.28631

Review

Review of Impact of COVID-19 on Maternal, Neonatal Outcomes, and Placental Changes

Resham Tanna et al. Cureus. 2022.

. 2022 Aug 31;14(8):e28631.

doi: 10.7759/cureus.28631. eCollection 2022 Aug.

Authors

Affiliations

¹ Obstetrics and Gynaecology, Spartan Health Sciences University, Vieux Fort, LCA.
² Obstetrics and Gynaecology, Rejuvenating Fertility Centre, New York, USA.
³ Obstetrics and Gynecology, Mamta Institute of Medical Sciences, Khammam, IND.
⁴ Obstetrics and Gynecology, Sekgoma Memorial Hospital, Serowe, BWA.
⁵ Obstetrics and Gynecology, Nyangabgwe Referral Hospital, Francistown, BWA.
⁶ Obstetrics and Gynecology, Gandhi Medical College, Musheerabad, IND.
⁷ Obstetrics and Gynaecology, Lifeline Medical Associates, New Jersey, USA.
⁸ Internal Medicine, Nilratan Sircar Medical College and Hospital, Kolkata, IND.
⁹ Obstetrics and Gynaecology, Ascension Health via Christi Hospital, Manhattan, USA.
¹⁰ Medical Sciences Department, Universidad Autonoma de Centro America (UACA), San José, CRI.
¹¹ Obstetrics and Gynaecology, Government Medical College Srinagar, Srinagar, IND.
¹² Obstetrics and Gynaecology, Ross University School of Medicine, Bridgetown, BRB.
¹³ Health Administration, Edward J. Bloustein School of Planning and Public Policy, New Jersey, USA.
¹⁴ Obstetrics and Gynecology, Annotto Bay Hospital, St.Mary, JAM.

PMID: 36106265
PMCID: PMC9450993
DOI: 10.7759/cureus.28631

Abstract

Coronavirus disease (COVID-19), caused by SARS-CoV-2, is a disease that has caused a global impact. COVID-19 is transmitted through airborne droplets, respiratory secretions, and direct contact. The pandemic has affected individuals of different ages, and studying the impact of COVID-19 on maternal and newborn outcomes is critical. In this review, we highlight the impact of COVID-19 infection in pregnancy and its repercussion in the maternal-fetal binomial. Physiological changes that occur during pregnancy have significant effects on the immune system, cardiopulmonary system, and coagulation, and these changes can result in an altered response to COVID-19 infection. The symptoms, risk factors, and maternal health consequences of COVID-19 were discussed. In addition, the impact of newborns born to mothers with COVID-19 was reviewed. Finally, placental changes and vertical transmission of COVID-19 during pregnancy were also discussed in this review.

Keywords: covid-19; maternal outcomes; neonatal outcomes; placental changes; pregnancy.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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[1] WHO Coronavirus (COVID-19) dashboard. [ Apr; 2022 ];https://covid19.who.int 2020

[2] WHO Coronavirus (COVID-19) dashboard. [ Apr; 2022 ];https://covid19.who.int 2020

[3] Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. Li Q, Guan X, Wu P, et al. N Engl J Med. 2020;382:1199–1207. - PMC - PubMed

[4] Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. Li Q, Guan X, Wu P, et al. N Engl J Med. 2020;382:1199–1207. - PMC - PubMed

[5] Epidemiology of coronavirus disease 2019 in pregnancy: risk factors and associations with adverse maternal and neonatal outcomes. Brandt JS, Hill J, Reddy A, et al. Am J Obstet Gynecol. 2021;224:389. - PMC - PubMed

[6] Epidemiology of coronavirus disease 2019 in pregnancy: risk factors and associations with adverse maternal and neonatal outcomes. Brandt JS, Hill J, Reddy A, et al. Am J Obstet Gynecol. 2021;224:389. - PMC - PubMed

[7] Characteristics and outcomes of 241 births to women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at five New York City medical centers. Khoury R, Bernstein PS, Debolt C, et al. Obstet Gynecol. 2020;136:273–282. - PubMed

[8] Characteristics and outcomes of 241 births to women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at five New York City medical centers. Khoury R, Bernstein PS, Debolt C, et al. Obstet Gynecol. 2020;136:273–282. - PubMed

[9] Disease severity and perinatal outcomes of pregnant patients with coronavirus disease 2019 (COVID-19) Metz TD, Clifton RG, Hughes BL, et al. Obstet Gynecol. 2021;137:571–580. - PMC - PubMed

[10] Disease severity and perinatal outcomes of pregnant patients with coronavirus disease 2019 (COVID-19) Metz TD, Clifton RG, Hughes BL, et al. Obstet Gynecol. 2021;137:571–580. - PMC - PubMed

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Review of Impact of COVID-19 on Maternal, Neonatal Outcomes, and Placental Changes

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Review of Impact of COVID-19 on Maternal, Neonatal Outcomes, and Placental Changes

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