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Review
. 2022 Dec;46(12):e14390.
doi: 10.1111/jfbc.14390. Epub 2022 Sep 15.

Diosgenin: An ingress towards solving puzzle for diabetes treatment

Prajya Arya  1 , Pradyuman Kumar  1
Affiliations
Review

Diosgenin: An ingress towards solving puzzle for diabetes treatment

Prajya Arya et al. J Food Biochem. 2022 Dec.

Abstract

The consumption and composition of food in daily life predict our health in long run. The relation of diabetes to sweets is quite popular. Diabetes hampers the glucose and insulin regulation in the human body by damaging pancreatic β cells. Diabetes has a strong potential towards altering cellular mechanisms of organs causing unlawful performance. Diabetes alters pathways like TLR4, AChE, NF-ĸB, LPL, and PPAR at different sites that affect the normal cellular machinery and cause damage to the local tissue and organ. The long-lasting effect of diabetes was observed in vascular, cardia, nervous, skeletal, reproductive, hepatic, ocular, and renal systems. The increasing awareness of diabetes and its concern has awakened the common people more enthusiastically. Due to rising harm from diabetes, scientific researchers tend to have more eyes toward it. While searching for diabetes solutions, fenugreek diosgenin could pop up with some positive effects in curing the same. Diosgenin helps to lower the scathe of diabetes by modifying cellular pathways in favor of healthy bodily functions. Diosgenin altered the pathways for renewal of pancreatic β cells for better insulin secretion, initiate GLUT4, enhanced DHEA, modify ER-α-mediated PI3K/Akt pathways. Diosgenin can be an appropriate insult for diabetes in a much evolving way for a healthy lifestyle. PRACTICAL APPLICATIONS: Diabetes is one of the most death causing diseases in the medical world. Regrettably the cure of diabetes is yet to be found. Various scientific team working on the same to look after the most appropriate way for diabetes treatment. There is enormous growth of nutraceutical in the market claiming for cure of different metabolic disorders. Among various bioactive compound fenugreek's diosgenin could took a leap over other in curing and preventing the damage caused by diabetes to different organs. The role of diosgenin in curing various metabolic disorders is quite popular from some time. This article also emphasizes over beneficiary effect of diosgenin in curing the damages caused by diabetes by altering cellular metabolism processes. Hence diosgenin could be a better way for researchers to develop a method for diabetes treatment.

Keywords: Cellular mechanism; Diabetes; Diabetes effect; Diosgenin; Metabolic disorder.

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References

REFERENCES

    1. Ahmed, D. A., EL Toony, L. F., El Kader, A. A., Esmail, A. M., Abass, W. A., & El Khated, H. (2019). Assessment of gestational diabetes in high-risk women attending Assiut University Women Health Hospital, Egypt. The Egyptian Journal of Internal Medicine, 31(4), 423-430. https://doi.org/10.4103/ejim.ejim_109_19
    1. Ahmed, L. A., Al Arqam, Z. O., Zaki, H. F., & Agha, A. M. (2014). Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats. European Journal of Pharmacology, 740, 379-387. https://doi.org/10.1016/j.ejphar.2014.07.026
    1. Alessi, D. R., & Cohen, P. (1998). Mechanism of activation and function of protein kinase B. Current Opinion in Genetics and Development, 8(1), 55-62. https://doi.org/10.1016/s0959-437x(98)80062-2
    1. Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., Ashworth, A., & Bownes, M. (1997). 3-Phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase. Current Biology, 7, 776-789. https://doi.org/10.1016/s0960-9822(06)00336-8
    1. Al-Khudairy, L., Stranges, S., Kumar, S., Al-Daghri, N., & Rees, K. (2013). Dietary factors and type 2 diabetes in the middle east: What is the evidence for an association? -a systematic review. Nutrients, 5(10), 3871-3897. https://doi.org/10.3390/nu5103871

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