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Meta-Analysis
. 2023 Mar 22;25(4):605-615.
doi: 10.1093/ntr/ntac213.

Meta-Analysis on Associations of Timing of Maternal Smoking Cessation Before and During Pregnancy With Childhood Overweight and Obesity

Jacob Perkins  1 , Tyler Re  1 , Sherry Ong  1 , Zhongzheng Niu  2 , Xiaozhong Wen  1
Affiliations
Meta-Analysis

Meta-Analysis on Associations of Timing of Maternal Smoking Cessation Before and During Pregnancy With Childhood Overweight and Obesity

Jacob Perkins et al. Nicotine Tob Res. .

Abstract

Introduction: There is a lack of comprehensive review on associations of maternal smoking cessation (versus nonsmokers) with childhood overweight and obesity.

Aims and methods: We conducted a systematic review and meta-analysis of existing evidence in this field. Within PubMed, EMBASE, and CENTRAL databases, we identified and screened 1147 abstracts. We reviewed full-texts and extracted related information from 10 eligible articles. We pooled odds ratios for overweight/obesity and mean differences in BMI z-scores by maternal smoking status around pregnancy.

Results: Among 10 eligible studies, 71 393 children were included from ages 2 to 18 years. Compared to children of nonsmokers, the pooled unadjusted odds ratio (OR) for overweight was 1.36 (95% Confidence Interval CI: 1.14, 1.62) in children of quitters and 1.44 (1.27, 1.64) in children of continued smokers. The pooled unadjusted OR for obesity was 1.65 (1.17, 2.32) in children of quitters and 1.94 (1.38, 2.73) in children of continued smokers. The pooled unadjusted mean difference in BMI z-score was 0.51 (0.41, 0.61) in children of quitters and 0.64 (0.58, 0.70) in children of continued smokers. The pooled unadjusted OR for overweight in children of mothers quitting before pregnancy was 1.46 (1.15, 1.85), during the first trimester was 1.52 (1.27, 1.82), and during pregnancy (mixed timing, mostly first trimester) was 0.97 (0.79, 1.20).

Conclusion: The risk of offspring overweight and obesity was moderately higher for quitters during pregnancy compared to nonsmokers, although it might not be as high as continued smokers.

Implications: Maternal smoking during pregnancy is an established risk factor of childhood overweight and obesity. Based on our systematic review, intervention to help mothers quit smoking has the potential to reduce the risk of childhood overweight and obesity in offspring related to prenatal tobacco exposure. Quitting before pregnancy is ideal, but quitting in early pregnancy is still helpful for reducing risk.

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Conflict of interest statement

No financial disclosures were reported by the authors of this paper.

Figures

Figure 1.
Figure 1.
Forest plot of pooled unadjusted OR for overweight in children of quitters (vs nonsmokers during pregnancy). OR, odds ratio; CI, confidence interval; T0, before pregnancy; T1, first trimester. Weights are from random effects analysis.
Figure 2.
Figure 2.
Forest plot of pooled unadjusted OR for obesity in children of quitters (vs nonsmokers during pregnancy) OR, odds ratio; CI, confidence interval. Weights are from random effects analysis.
See this image and copyright information in PMC

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