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Review
. 2022 Nov;125(11):839-848.
doi: 10.1007/s00113-022-01237-1. Epub 2022 Sep 15.

[Clinical diagnostics, differential diagnostics, pathogenesis and stage model of arthrofibrosis]

[Article in German]
Affiliations
Review

[Clinical diagnostics, differential diagnostics, pathogenesis and stage model of arthrofibrosis]

[Article in German]
Philipp Traut. Unfallchirurgie (Heidelb). 2022 Nov.

Abstract

Arthrofibrosis (AF) is one of the most frequent complications of injuries and surgical interventions on joints, particularly after total knee replacement and anterior cruciate ligament reconstruction. Even though all joints can be affected, most cases involve the knee joint. Patients feel a painful impairment of the range of motion caused by fibrotic tissue formation within and sometimes also outside the joint. The normal healing process is disturbed by mechanical and emotional stressors and severe pain. In 90% of the cases AF occurs even within the first few days after the injury or surgery, so that the quality standards cannot be achieved. Physiotherapy and rehabilitation often do not result in a substantial amelioration of symptoms, so that the activities of daily living (ADL) are severely limited. The clinical diagnostics, differential diagnostics and a novel pathogenesis and stage model of the primary AF with the treatment principles derived from this are presented in this article.

Die Arthrofibrose (AF) gehört zu den häufigsten Komplikationen nach Verletzungen und operativen Eingriffen an Gelenken, v. a. nach Gelenk- und Kreuzbandersatz. Alle großen Gelenke können betroffen sein, am häufigsten ist es jedoch das Kniegelenk. Es kommt zur schmerzhaften Bewegungseinschränkung durch Vermehrung von fibrotischem Gewebe innerhalb und teilweise auch außerhalb des Gelenks. Der normale Heilungsprozess ist durch mechanische und emotionale Stressoren sowie starke Schmerzreize gestört. Die AF tritt zu 90 % schon wenige Tage nach der Verletzung oder Operation auf, sodass die Qualitätsstandards nicht erreicht werden können. Durch Physiotherapie und Rehabilitation kann oft keine wesentliche Verbesserung der Funktion erreicht werden, sodass die Aktivitäten des täglichen Lebens (ADL) stark eingeschränkt sind. Klinische Diagnostik, Differenzialdiagnostik sowie ein neues Pathogenese- und Stadienmodell der primären AF mit den daraus abgeleiteten therapeutischen Prinzipien werden vorgestellt.

Keywords: Cruciate ligament; Joint replacement; Knee; Scarring; Stiffness.

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References

    1. Aarabi S, et al. Mechanical load initiates hypertrophic scars formation through decreased cellular apoptosis. FASEB J. 2007;21:3250–3261. doi: 10.1096/fj.07-8218com. - DOI - PubMed
    1. Bierke S, et al. Risk of arthrofibrosis in anatomical anterior cruciate ligament rekonstuction: the role of timing and meniscus suture. Arch Orthop Trauma Surg. 2021;141(5):743–750. doi: 10.1007/s00402-020-03464-w. - DOI - PubMed
    1. Bleß HH, Kip M. Weißbuch Gelenkersatz. Versorgungssituation endoprothetischer Hüft- und Knieoperationen in Deutschland. Heidelberg, Berlin, New York: Springer; 2017.
    1. Cheuy VA, Foran JRH, Paxton RJ, Bade MJ, Zeni JA, Stevens-Lapsley JE. Arthrofibrosis associated with total knee arthroplasty. J Arthroplasty. 2017;32(8):2604–2611. doi: 10.1016/j.arth.2017.02.005. - DOI - PubMed
    1. Dunbar MJ, Richardson G, Robertsson O. I can’t get no satisfaction after my total knee replacement. Bone Joint J. 2013;95-B(Supple A):148–152. doi: 10.1302/0301-620X.95B11.32767. - DOI - PubMed

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