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. 2022 Sep 1;5(9):e2231878.
doi: 10.1001/jamanetworkopen.2022.31878.

Subclinical Risk Factors for Heart Failure With Preserved and Reduced Ejection Fraction Among Black Adults

Li Zhao  1   2 , Rani Zierath  1 , Jenine E John  1 , Brian Lee Claggett  1 , Michael E Hall  3 , Donald Clark 3rd  3 , Kenneth R Butler  3 , Adolfo Correa  3 , Amil M Shah  1
Affiliations

Subclinical Risk Factors for Heart Failure With Preserved and Reduced Ejection Fraction Among Black Adults

Li Zhao et al. JAMA Netw Open. .

Abstract

Importance: Sparse data exist regarding the contributions of subclinical impairments in cardiovascular and noncardiovascular function to incident heart failure (HF) with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF) among Black US residents, limiting understanding of the etiology of HF subtypes.

Objectives: To identify subclinical cardiovascular and noncardiovascular risk factors associated with HFrEF and HFpEF in Black US residents.

Design, setting, and participants: This cohort study used cross-sectional and time-to-event analysis with data from the community-based Jackson Heart Study (JHS), a longitudinal cohort study with baseline data collected from 2000 to 2004 (visit 1) and 10-year follow-up for incident HF. Black US residents from the Jackson, Mississippi, metropolitan area enrolled in JHS; those with prevalent HF, with moderate or greater aortic or mitral valve diseases on visit 1, who died before 2005, and who had missing HF status on follow-up were excluded. The analysis included 4361 participants and was performed between June 2020 to August 2021.

Exposures: Quantitative measures of cardiovascular (left ventricular mass index [LVMI], left ventricular ejection fraction [LVEF], left atrial [LA] diameter, and pulse pressure) and noncardiovascular (percent predicted forced expiration volume in 1 second [FEV1 (percent predicted)], estimated glomerular filtration rate (eGFR), waist circumference, and hemoglobin A1c [HbA1c] level) organ function.

Main outcomes and measures: Incident HF, HFrEF, and HFpEF over 10-year follow-up.

Results: The 4361 participants had a mean (SD) age of 54 (13); 2776 (64%) were women; and there were 163 HFpEF and 146 HFrEF events. In multivariable models incorporating measures reflecting each organ system, factors associated with incident HFpEF included greater LA diameter (hazard ratio [HR], 1.23; 95% CI, 1.03-1.47; P = .02), higher pulse pressure (HR, 1.23; 95% CI, 1.05-1.44; P = .009), lower FEV1 (percent predicted) (HR, 1.22; 95% CI, 1.04-1.43; P = .02), lower eGFR (HR, 1.43; 95% CI, 1.19-1.72; P < .001), higher HbA1c level (HR, 1.25; 95% CI, 1.07-1.45; P = .005), and higher waist circumference (HR, 1.41; 95% CI, 1.18-1.69; P < .001). Factors associated with incident HFrEF included greater LVMI (HR, 1.25; 1.07-1.46; P = .005), lower LVEF (HR, 1.65; 95% CI, 1.42-1.91; P < .001), lower FEV1 (percent predicted) (HR, 1.19; 95% CI, 1.00-1.42; P = .047), and lower eGFR (HR, 1.27; 95% CI, 1.04-1.55; P = .02).

Conclusions and relevance: In this community-based cohort study of Black US residents, subclinical impairments in cardiovascular and noncardiovascular organ function were differentially associated with risk of incident HFpEF and HFrEF.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr John reported receiving grants from the National Institutes of Health (NIH) outside the submitted work. Dr Claggett reported receiving consulting fees from Myokardia, Gilead, AOBiome, Boehringer Ingelheim, Novartis, Cardurion, Corvia, and Amgen outside the submitted work. Dr Shah reported receiving research support from Novartis and Philips Ultrasound through Brigham and Women’s Hospital and serving on the advisory board of Philips Ultrasound and Janssen Pharmaceuticals outside the submitted work. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Cardiovascular and Noncardiovascular Factors Associated With Incident Heart Failure With Preserved Ejection Fraction (HFpEF) and Heart Failure With Reduced Ejection Fraction (HFrEF)
The standardized hazard ratio (HR)–HR plot shows independent factors associated with HFrEF, including left ventricular ejection fraction (LVEF) and left ventricular mass index (LVMI), and for HFpEF, including left atrial diameter (LAD), pulse pressure (PP), hemoglobin A1c (HbA1c) level, and waist circumference (waist), and for both HFrEF and HFpEF, including estimated glomerular filtration rate (eGFR) and percent predicted forced expiration volume in 1 second (ppFEV1).
Figure 2.
Figure 2.. Associations of Socioeconomic Metrics With Incident Heart Failure (HF) Events
The associations of some socioeconomic measures (income status and education attainment) with incident HF or HF subtypes (adjusted for age, sex, hypertension, diabetes, smoking status, and coronary heart disease history) were attenuated when further adjusted for cardiovascular (CV) risk score, non-CV score, or both. The reference level for income status was affluent, and the reference level for education attainment was vocational school, trade school, or college. HR indicates hazard ratio; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction.
See this image and copyright information in PMC

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