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. 2022 Aug 29:22:100492.
doi: 10.1016/j.lanepe.2022.100492. eCollection 2022 Nov.

Lung cancer trends and tumor characteristic changes over 20 years (2000-2020): Results of three French consecutive nationwide prospective cohorts' studies

Didier Debieuvre  1 , Olivier Molinier  2 , Lionel Falchero  3 , Chrystèle Locher  4 , Dorine Templement-Grangerat  5 , Nicolas Meyer  6 , Hugues Morel  7 , Yannick Duval  8 , Bernard Asselain  9 , Alexia Letierce  10 , Jean Trédaniel  11 , Jean-Bernard Auliac  12 , Olivier Bylicki  13 , Lionel Moreau  14 , Mathieu Fore  1 , Romain Corre  15 , Sébastien Couraud  16 , Alexis Cortot  17 ; Study Group KBP-2020-CPHG; KBP-2020-CPHG
Collaborators, Affiliations

Lung cancer trends and tumor characteristic changes over 20 years (2000-2020): Results of three French consecutive nationwide prospective cohorts' studies

Didier Debieuvre et al. Lancet Reg Health Eur. .

Abstract

Background: Long-term changes in lung cancer (LC) patients are difficult to evaluate. We report results from the French KBP-2020 real-life cohort.

Methods: KBP-2020 was a prospective cohort that included all patients diagnosed with LC in 2020, in nonacademic public hospital in France. Patient and tumour characteristics were described and compared with similarly designed cohorts in 2000 and 2010.

Findings: In 2020, 82 centers included 8,999 patients diagnosed with LC. The proportion of women increased: 34·6% (3114/8999) compared to, 24·3% (1711/7051) and 16·0% (904/5667) in 2010 and 2000 (p<0·0001). The proportion of non-smokers was higher in 2020 (12·6%, 1129/8983) than in previous cohorts (10·9% (762/7008) in 2010; 7·2% (402/5586) in 2000, p<0·0001). In 2020, at diagnosis, 57·6% (4405/7648) of patients had a metastatic/disseminated stage non-small-cell lung cancer (NSCLC) (58·3% (3522/6046) in 2010; 42·6% (1879/4411) in 2000, p<0·0001). Compared with 2000 and 2010 data, early survival improved slightly. In 2020, 3-month mortality of NSCLC varied from 3·0% [2·2 - 3·8] for localized to 9·6% [8·1 - 11·0] for locally advanced to 29·2% [27·8 - 30·6] for metastatic and was 24·8% [22·3 - 27·3] for SCLC.

Interpretation: To our knowledge KBP cohorts have been the largest, prospective, real-world cohort studies involving LC patients conducted in worldwide. The trend found in our study shows an increase in LC in women and still a large proportion of patients diagnosed at metastatic or disseminated stage.

Funding: The study was promoted by the French College of General Hospital Pulmonologists with financial support of industrials laboratories.

Keywords: Adenocarcinoma; CPHG, French College of General Hospital Pulmonologists; Early mortality; Epidemiology; LC, Lung Cancer; Lung cancer; NPH, Nonacademic public hospitals; NSCLC, Non-small-cell lung cancer; Non-small-cell lung cancer; PS, Performance status; Real-life; SCLC, Small-cell lung cancer; Small-cell lung cancer; Smoking habits; TMB, Tumour molecular burden; Tumor characteristics.

PubMed Disclaimer

Conflict of interest statement

The authors have no financial and personal relationship with other people or organization that could inappropriately bias this work. The scientific committee was fully independent from industrial sponsors.

Figures

Figure 1
Figure 1
Flowchart of study populations.
Figure 2
Figure 2
Lung cancer cases distribution according to age in males and females in KBP-cohorts.
Figure 3
Figure 3
Absolute numbers of lung cancer cases according to age in males and females in KBP-cohorts.
Figure 4
Figure 4
KBP-2000-2010-2020 centers - Venn diagram.
See this image and copyright information in PMC

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