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Comment
. 2022 Oct:106:106903.
doi: 10.1016/j.ijsu.2022.106903. Epub 2022 Sep 13.

Immediate need for next-generation and mutation-proof vaccine to protect against current emerging Omicron sublineages and future SARS-CoV-2 variants: An urgent call for researchers and vaccine companies - Correspondence

Chiranjib Chakraborty  1 , Manojit Bhattacharya  2 , Ashish Ranjan Sharma  3 , Ranjan K Mohapatra  4 , Sandip Chakraborty  5 , Soumen Pal  6 , Kuldeep Dhama  7
Affiliations
Comment

Immediate need for next-generation and mutation-proof vaccine to protect against current emerging Omicron sublineages and future SARS-CoV-2 variants: An urgent call for researchers and vaccine companies - Correspondence

Chiranjib Chakraborty et al. Int J Surg. 2022 Oct.
No abstract available

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Conflict of interest statement

Declaration of competing interest All authors report no conflicts of interest relevant to this article.

Figures

Fig. 1
Fig. 1
Emerging mutations in SARS-CoV-2 are responsible for neutralizing antibodies (nAbs) escape and vaccine escape. These mutations should be considered to develop a mutation-proof, next-generation vaccine against pan-SARS-CoV-2 variants. For significant mutation selection, first, we listed all the mutations from all the SARS-CoV-2 variants (VOCs, VOIs, and VUMs), including Omicron and its emerging sublineages. From the list of mutations, we have selected vital mutations considering the frequencies and the characteristics of mutations (stability, molecular flexibility, etc.).
See this image and copyright information in PMC

Comment on

  • Omicron, the great escape artist.
    Flemming A. Flemming A. Nat Rev Immunol. 2022 Feb;22(2):75. doi: 10.1038/s41577-022-00676-6. Nat Rev Immunol. 2022. PMID: 35017722 Free PMC article.

References

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    1. WHO Tracking SARS-CoV-2 variants. 2022. https://www.who.int/activities/tracking-SARS-CoV-2-variants
    1. Flemming A. Omicron, the great escape artist. Nat. Rev. Immunol. 2022;22(2):75. Epub 2022/01/13. - PMC - PubMed
    1. Cao Y., Wang J., Jian F., Xiao T., Song W., Yisimayi A., et al. Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature. 2022;602(7898):657–663. Epub 2022/01/12. - PMC - PubMed
    1. Planas D., Saunders N., Maes P., Guivel-Benhassine F., Planchais C., Buchrieser J., et al. Considerable escape of SARS-CoV-2 Omicron to antibody neutralization. Nature. 2022;602(7898):671–675. Epub 2022/01/12. - PubMed

Supplementary concepts