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Comment
. 2022 Sep;28(9):1755-1756.
doi: 10.1038/s41591-022-01998-7.

CAR Treg cells: prime suspects in therapeutic resistance

Neeraj Saini  1   2 , Sattva S Neelapu  3
Affiliations
Comment

CAR Treg cells: prime suspects in therapeutic resistance

Neeraj Saini et al. Nat Med. 2022 Sep.

Abstract

Using comprehensive single-cell profiling, two studies reveal the molecular phenotypes of CAR T cells associated with durable response in patients with lymphoma, and highlight the role of CAR regulatory T cells in mediating resistance.

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Figures

Fig. 1:
Fig. 1:. CAR Treg cells are associated with poor responses to anti-CD19 CAR T cell therapy in patients with lymphoma.
Higher numbers of CAR Treg cells in CAR products and their subsequent proliferation after infusion suppresses the proliferation and function of conventional cytotoxic CAR T cells, leading to increased tumor growth.
See this image and copyright information in PMC

Comment on

  • Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma.
    Haradhvala NJ, Leick MB, Maurer K, Gohil SH, Larson RC, Yao N, Gallagher KME, Katsis K, Frigault MJ, Southard J, Li S, Kann MC, Silva H, Jan M, Rhrissorrakrai K, Utro F, Levovitz C, Jacobs RA, Slowik K, Danysh BP, Livak KJ, Parida L, Ferry J, Jacobson C, Wu CJ, Getz G, Maus MV. Haradhvala NJ, et al. Nat Med. 2022 Sep;28(9):1848-1859. doi: 10.1038/s41591-022-01959-0. Epub 2022 Sep 12. Nat Med. 2022. PMID: 36097221 Free PMC article.
  • Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy.
    Good Z, Spiegel JY, Sahaf B, Malipatlolla MB, Ehlinger ZJ, Kurra S, Desai MH, Reynolds WD, Wong Lin A, Vandris P, Wu F, Prabhu S, Hamilton MP, Tamaresis JS, Hanson PJ, Patel S, Feldman SA, Frank MJ, Baird JH, Muffly L, Claire GK, Craig J, Kong KA, Wagh D, Coller J, Bendall SC, Tibshirani RJ, Plevritis SK, Miklos DB, Mackall CL. Good Z, et al. Nat Med. 2022 Sep;28(9):1860-1871. doi: 10.1038/s41591-022-01960-7. Epub 2022 Sep 12. Nat Med. 2022. PMID: 36097223 Free PMC article.

References

    1. Neelapu SS et al. N. Engl. J. Med 377, 2531–2544 (2017). - PMC - PubMed
    1. Jacobson CA et al. Lancet Oncol. 23, 91–103 (2022). - PubMed
    1. Schuster SJ et al. N. Engl. J. Med 380, 45–56 (2019). - PubMed
    1. Haradhvala NJ et al. Nat. Med 10.1038/s41591-022-01959-0 (2022). - DOI
    1. Good Z. et al. Nat. Med 10.1038/s41591-022-01960-7 (2022). - DOI

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