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. 2022 Sep 15;22(1):230.
doi: 10.1186/s12902-022-01148-7.

Clinical, metabolic, and immunological characterisation of adult Ugandan patients with new-onset diabetes and low vitamin D status

Davis Kibirige  1   2 , Isaac Sekitoleko  3 , Priscilla Balungi  3   4 , Jacqueline Kyosiimire-Lugemwa  4 , William Lumu  5
Affiliations

Clinical, metabolic, and immunological characterisation of adult Ugandan patients with new-onset diabetes and low vitamin D status

Davis Kibirige et al. BMC Endocr Disord. .

Abstract

Background: Low vitamin D concentrations are associated with metabolic derangements, notably insulin resistance and pancreatic beta-cell dysfunction in Caucasian populations. Studies on its association with the clinical, metabolic, and immunologic characteristics in black African adult populations with new-onset diabetes are limited. This study aimed to describe the clinical, metabolic, and immunologic characteristics of a black Ugandan adult population with recently diagnosed diabetes and hypovitaminosis D.

Methods: Serum vitamin D concentrations were measured in 327 participants with recently diagnosed diabetes. Vitamin D deficiency, vitamin D insufficiency, and normal vitamin D status were defined as serum 25 hydroxyvitamin D levels of < 20 ng/ml, 21-29 ng/ml, and ≥ 30 ng/ml, respectively.

Results: The median (IQR) age, glycated haemoglobin, and serum vitamin D concentration of the participants were 48 years (39-58), 11% (8-13) or 96 mmol/mol (67-115), and 24 ng/ml (18-30), respectively. Vitamin D deficiency, vitamin D insufficiency, and normal vitamin D status were noted in 105 participants (32.1%), 140 participants (42.8%), and 82 participants (25.1%), respectively. Compared with those having normal serum vitamin D levels, participants with vitamin D deficiency and insufficiency had higher circulating concentrations of interleukin (IL) 6 (29 [16-45] pg/ml, 23 [14-40] pg/ml vs 18 [14-32] pg/ml, p = 0.01), and IL-8 (24 [86-655] pg/ml, 207 [81-853] pg/ml vs 98 [67-224], p = 0.03). No statistically significant differences were noted in the markers of body adiposity, insulin resistance, and pancreatic beta-cell function between both groups.

Conclusion: Vitamin D deficiency and insufficiency were highly prevalent in our study population and were associated with increased circulating concentrations of pro-inflammatory cytokines. The absence of an association between pancreatic beta-cell function, insulin resistance, and low vitamin D status may indicate that the latter does not play a significant role in the pathogenesis of type 2 diabetes in our adult Ugandan population.

Keywords: African population; Newly diagnosed diabetes; Sub-Saharan Africa; Uganda; Vitamin D deficiency; Vitamin D insufficiency.

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Conflict of interest statement

All the authors report no conflict of interest.

Figures

Fig. 1
Fig. 1
Box plots showing the differences in the circulating log concentrations of IL-6 and IL-8 between participants with vitamin D deficiency, vitamin D insufficiency, and normal vitamin D status
See this image and copyright information in PMC

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References

    1. Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, TmavaBerisha A, Martucci G, Pilz S, Malle O. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020;74(11):1498–1513. doi: 10.1038/s41430-020-0558-y. - DOI - PMC - PubMed
    1. Roth DE, Abrams SA, Aloia J, Bergeron G, Bourassa MW, Brown KH, Calvo MS, Cashman KD, Combs G, De-Regil LM, et al. Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries. Ann N Y Acad Sci. 2018;1430(1):44–79. doi: 10.1111/nyas.13968. - DOI - PMC - PubMed
    1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–281. doi: 10.1056/NEJMra070553. - DOI - PubMed
    1. Mogire RM, Mutua A, Kimita W, Kamau A, Bejon P, Pettifor JM, Adeyemo A, Williams TN, Atkinson SH. Prevalence of vitamin D deficiency in Africa: a systematic review and meta-analysis. Lancet Glob Health. 2020;8(1):e134–e142. doi: 10.1016/S2214-109X(19)30457-7. - DOI - PMC - PubMed
    1. Prentice A, Schoenmakers I, Jones KS, Jarjou LMA, Goldberg GR. Vitamin D Deficiency and Its Health Consequences in Africa. Clin Rev Bone Miner Metab. 2009;7(1):94–106. doi: 10.1007/s12018-009-9038-6. - DOI - PMC - PubMed