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. 2022 Aug 30:10:956058.
doi: 10.3389/fbioe.2022.956058. eCollection 2022.

Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study

Jianjing Lin  1   2   3 , Zhen Yang  1   2 , Li Wang  4 , Dan Xing  1   2 , Jianhao Lin  1   2
Affiliations

Global research trends in extracellular vesicles based on stem cells from 1991 to 2021: A bibliometric and visualized study

Jianjing Lin et al. Front Bioeng Biotechnol. .

Abstract

Objective: With the development of extracellular vesicles (EVs) based on stem cells research all over the world, our present study was aiming to discover the global trends in this field. Methods: All publications related to EVs based on stem cells from 1991 to 2021 were collected from the Science Citation Index-Expanded of Web of Science Subsequently, the data were evaluated using the bibliometric methodology. In terms of visualized study, the VOS viewer software was performed to investigate the bibliographic coupling, co-citation, co-authorship, and co-occurrence trends, and last for the publication's trends involved in the field of EVs based on stem cells. Results: A total of 8,208 publications were retrieved and the relative number of global publications and research interests were increasing every year especially in recent 5 years. China rank top one in terms of total publications, prolific authors, and funds, whereas the USA made the greatest contributions with the most total citations and highest H-index to the global research. Stem cell research therapy contributed the highest publications, whereas the journal of PLOS ONE showed the best total link strength. The Shanghai Jiao Tong University, University of California System, and Harvard University were the most contributive institutions. The global studies could be divided into six clusters as follows: cancer research, musculoskeletal system research, respiratory system research, urinary system and endocrine system research, nerve system research, and cardiovascular system research. All the directions were predicted to still hotspots in near future researches in this field. Conclusion: The total number of publications about EVs based stem cells would be increasing according to the current global trends. China and the USA was the largest contributors in this field. Further efforts should be put in the directions of cancer research, musculoskeletal system research, respiratory system research, urinary system and endocrine system research, nerve system research, as well was cardiovascular system research in this field of EVs based stem cells.

Keywords: bibliometrics; extracellular vesicles; global research trend; stem cells; visualized study.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Global trends and countries/regions contributing to extracellular vesicles (EVs) based on stem cells research. (A) The global number and relative research interests of publications related to EVs based on stem cells research. The blue bars mean the publication numbers each year, and the black curve meas the relative research interests. (B) Distribution of EVs based on stem cells research in world map. (C) The sum of EVs based on stem cells related publications from the top 25 countries and regions. (D) Model fitting curves of global trends in publications of EVs based on stem cells.
FIGURE 2
FIGURE 2
Citation frequency and H index levels of different countries and regions. (A) The top 25 countries and regions of total citations of EVs based on stem cells research publications. (B) The top 25 countries and regions of the average citations per paper of EVs based on stem cells research publications. (C) The top 25 countries and regions of the H-index of EVs based on stem cells research publications.
FIGURE 3
FIGURE 3
High-contribution journals, authors, research orientations, institutions and funds of global publications about EVs based on stem cells. (A) The top 25 journals with most publications related to EVs based on stem cells. (B) The top 25 authors with most publications related to EVs based on stem cells. (C) The top 25 research orientations with most publications related to EVs based on stem cells. (D) The top 25 institutions with most publications related to EVs based on stem cells. (E) The top 25 funds with most publications related to EVs and stem cells.
FIGURE 4
FIGURE 4
Mapping of bibliographic coupling analysis related to EVs based on stem cells. (A) Mapping of the 354 identified journals on EVs based on stem cells. (B) Mapping of the 834 institutions on EVs based on stem cells. (C) Mapping of the 62 countries on EVs based on stem cells. (D) Mapping of the 1,090 authors on EVs based on stem cells. The line between different points represents that the journals/institutions/countries/authors had establish a similarity relationship. The thicker the line, the closer the link between the journals/institutions/countries/authors.
FIGURE 5
FIGURE 5
Mapping of co-citation related to EVs based on stem cells. (A) Mapping of the co-cited references related to this field (The 927 points with different colors represent the 927 cited references.) (B) Mapping of the co-cited journals related to this field (The 1,269 points with different colors represent the 1,269 identified journals.) (C) Mapping of the co-cited authors related to this field (The 1,558 points with different colors represent the 1,558 identified journals.) The point sizes represent the citation frequency. The line between different points indicates that they were cited in one paper. The shorter the line, the closer the link between two papers. The same color of the points represents the same research area they belong to.
FIGURE 6
FIGURE 6
Co-authorship analysis of global research about EVs based on stem cells. (A) Mapping of the 1090-author co-authorship analysis on EVs based on stem cells. (B) Mapping of the 834-institution co-authorship analysis on EVs based on stem cells. (C) Mapping of the 62-country co-authorship analysis on EVs based on stem cells. The line between two points represents the establishment of collaboration within two authors/institutions/countries, where the thickness indicates the collaboration strength between the two authors/institutions/countries.
FIGURE 7
FIGURE 7
Co-occurrence analysis of global research about EVs based on stem cells. (A) Mapping of keywords in the research on EVs based on stem cells; the frequency is represented by point size and the keywords of research fields are divided into six clusters: cancer research (red), musculoskeletal system research (green), respiratory system research (dark blue), urinary system and endocrine system research (yellow), nerve system research (purple), and cardiovascular system research (pink) .(B) Distribution of keywords according to the mean frequency of appearance; keywords in yellow appeared later than those in blue.
FIGURE 8
FIGURE 8
Citespace analysis of global research about EVs based on stem cells. Top 25 Keywords with the Strongest Citation Bursts.
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