doi: 10.1093/ofid/ofac427.
eCollection 2022 Sep.
Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality
Affiliations
- PMID: 36111172
- PMCID: PMC9452087
- DOI: 10.1093/ofid/ofac427
Item in Clipboard
Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality
Open Forum Infect Dis.
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Erratum in
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Correction to: Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality.Open Forum Infect Dis. 2023 Jan 18;10(1):ofad012. doi: 10.1093/ofid/ofad012. eCollection 2023 Jan. Open Forum Infect Dis. 2023. PMID: 36686634 Free PMC article.
Abstract
In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals.
Keywords: COVID-19; endothelial damage; inflammation; metabolic biomarkers.
Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.
Figures
Logistic regression of clinical characteristics and biomarkers associated with severe–critical disease (A) and death (B) from COVID-19, adjusted for time from symptom onset to specimen collection. Multiparameter Spearman’s correlation analysis was used to generate heat maps demonstrating correlations between biomarkers in those with mild–moderate COVID-19 (C) and severe–critical disease (D) (statistically significant [P < .05] correlations are highlighted by colored circles, with red indicating positive and yellow highlighting negative assocations). The total number of positive correlations (r > 0.30) was notably different between those with mild–moderate disease compared with severe–critical. No negative correlations with r < –0.30 were identified. Abbreviations: ALC, absolute lymphocyte count; ANC, absolute neutrophil count; AT3, antithrombin III; BMI, body mass index; CIC-C1q, circulating immune complexes–C1q; COPD, chronic obstructive pulmonary disease; COVID-19, coronavirus disease 2019; CRP, C-reactive protein; IFNγ, interferon-γ; IL-6Rα, interleukin-6 receptor-α; PAD-4, peptidylarginine deaminase–4; PTX3, pentraxin-3; SAA, serum amyloid A; sICAM-1, soluble intercellular adhesion molecule–1; sVCAM-1, soluble vascular cell adhesion molecule-1; TFPI, tissue factor pathway inhibitor; TM, thrombomodulin; TNFα, tumor necrosis factor-α; TPO, thrombopoietin.
