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. 2023 Jan 1;21(1):243-253.
doi: 10.11124/JBIES-21-00378.

Effectiveness of osteopathic manipulative treatment in cardiovascular function: a systematic review protocol

Cheryl Vanier  1   2 , Kristine Johnston  1 , Megan DeArmond  1   2 , Liza Salloum  1 , Shadi Arjmand  1 , Eric Toder  1 , Marina Ioudina  1
Affiliations

Effectiveness of osteopathic manipulative treatment in cardiovascular function: a systematic review protocol

Cheryl Vanier et al. JBI Evid Synth. .

Abstract

Objective: The objective of this review is to investigate the short- and long-term effects of osteopathic manipulative treatment on cardiovascular function and its regulators in the nervous and endocrine systems.

Introduction: A variety of pharmacological and lifestyle-based treatments are used to prevent or treat vascular diseases, yet vascular disease underpins the top 2 causes of death worldwide. There is a need for more preventative and therapeutic interventions in the management and prevention of vascular disease that are compatible with existing interventions. Osteopathic manipulative treatment has shown promise as a non-invasive approach to improve cardiovascular function, but it is currently utilized mostly for alleviating musculoskeletal symptoms. A comprehensive summary of the evidence on the effectiveness of osteopathic manipulative treatment in cardiovascular function will assist clinicians and guide future research directions.

Inclusion criteria: This review will consider randomized controlled trials, non-randomized controlled trials, and crossover studies. Participants must have received osteopathic manipulative treatment intervention. Comparators will include passive or active controls, including controls for body position, touch, and other potential interventions for vascular disease. Cardiovascular, nervous-system, or endocrine-system outcome variables must be measured at least once after treatment. Adverse events will also be considered.

Methods: Searches will be conducted in the following sources: MEDLINE, the Journal of Osteopathic Medicine , Embase, Scopus, ProQuest One Academic, MedNar, the International Journal of Osteopathic Medicine , and CINAHL. Studies available in English, without date restrictions, will be considered for inclusion. Relevant studies will be selected by 2 independent reviewers, critically appraised, and extracted using a tool customized for the details of the study. If meta-analysis is possible, evidence will be summarized using standard techniques with subgroup analyses providing more insight into particular osteopathic manipulative treatment techniques, time frame of the treatment, and duration of effects, among others. Certainty of findings will be presented using GRADE.

Systematic review registration number: PROSPERO CRD42021225838.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Global Health Estimates 2020: Deaths by cause, age, sex, by country and by region, 2000-2019. Geneva: World Health Organization; 2020.
    1. Zhou D, Xi B, Zhao M, Wang L, Veeranki SP. Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study. Sci Rep 2018;8(1):9418.
    1. Antonakoudis G, Poulimenos L, Kifnidis K, Zouras C, Antonakoudis H. Blood pressure control and cardiovascular risk reduction. Hippokratia 2007;11(3):114–119.
    1. Carey RM, Calhoun DA, Bakris GL, Brook RD, Daugherty SL, Dennison-Himmelfarb CR, et al. Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association. Hypertension 2018;72(5):e53–e90.
    1. Persell SD. Prevalence of resistant hypertension in the United States, 2003-2008. Hypertension 2011;57(6):1076–1080.

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