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. 2022 Sep;26(17):6114-6120.
doi: 10.26355/eurrev_202209_29629.

The relationship between papillary thyroid cancer and triglyceride/glucose index, which is an indicator of insulin resistance

E G Alkurt  1 , F Şahin, B Tutan, K Canal, V B Turhan
Affiliations
Free article

The relationship between papillary thyroid cancer and triglyceride/glucose index, which is an indicator of insulin resistance

E G Alkurt et al. Eur Rev Med Pharmacol Sci. 2022 Sep.
Free article

Abstract

Objective: The incidence of thyroid cancer and metabolic syndrome has been increasing at the same rate over the past few decades. We hypothesized that there would be a direct relationship between thyroid papillary cancer and triglyceride/glucose index (TyG).

Patients and methods: A total of 382 operated patients were divided into two groups: patients operated on for papillary thyroid cancer and for non-malignant reasons. Each patient's age, gender, operation times, presence of neck dissection, serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4), fasting blood glucose and triglyceride levels were scanned retrospectively from the archive system.

Results: TyG index was statistically higher in the malignant group. Receiver operating characteristic (ROC) curves obtained for TyG levels at the time of diagnosis of thyroid papillary cancer were AUC: 0.608. The threshold value for TyG was 6,252. The sensitivity of this value was 62.8% and the specificity was 49.2%.

Conclusions: In this study, we investigated the predictive effect of the TyG index in differentiating thyroid papillary carcinoma from non-malignant thyroid lesions. We concluded that the TgY index can be used to identify people at high risk of thyroid papillary cancer and to plan treatment.

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