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. 2023 Jan-Feb;47(1):115-120.
doi: 10.1097/RCT.0000000000001379. Epub 2022 Sep 7.

Contrast Enhancement Patterns in Pediatric Glioblastomas

Halyna Pokhylevych  1 , Swapnil Khose  1 , Maria K Gule-Monroe  1 , Melissa M Chen  1 , Greg Fuller  2 , Stephen K Gruschkus  3 , Zsila Sadighi  4 , Wafik Zaky  4 , David I Sandberg  5 , Susan L McGovern  6 , Jason M Johnson  1
Affiliations

Contrast Enhancement Patterns in Pediatric Glioblastomas

Halyna Pokhylevych et al. J Comput Assist Tomogr. 2023 Jan-Feb.

Abstract

Background and purpose: Brain tumors are the most common cause of cancer-related deaths among the pediatric population. Among these, pediatric glioblastomas (GBMs) comprise 2.9% of all central nervous system tumors and have a poor prognosis. The purpose of this study is to determine whether the imaging findings can be a prognostic factor for survival in children with GBMs.

Materials and methods: The imaging studies and clinical data from 64 pediatric patients with pathology-proven GBMs were evaluated. Contrast enhancement patterns were classified into focal, ring-like, and diffuse, based on preoperative postcontrast T1-weighted magnetic resonance images. We used the Kaplan-Meier method and Cox proportional hazard regression to evaluate the prognostic value of imaging findings.

Results: Patients with ring-enhanced GBMs who underwent gross total resection or subtotal resection were found to have a significantly shorter progression-free survival ( P = 0.03) comparing with other enhancing and nonenhancing glioblastomas.

Conclusions: In this study, we analyzed survival factors in children with pediatric glioblastomas. In the group of patients who underwent gross total resection or subtotal resection, those patients with focal-enhanced GBMs had significantly longer progression-free survival ( P = 0.03) than did those with other types of enhancing GBMs (diffuse and ring-like).

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Conflict of interest statement

The authors declare no conflict of interest.

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