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Comment
. 2022 Oct 3;221(10):e202208164.
doi: 10.1083/jcb.202208164. Epub 2022 Sep 16.

Endosomal recycling defects link Huntington's disease with McLeod syndrome

Elise Marsan  1 , Eric J Huang  1   2
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Comment

Endosomal recycling defects link Huntington's disease with McLeod syndrome

Elise Marsan et al. J Cell Biol. .

Abstract

Chhetri and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces manganese transport across cell membrane.

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Figures

Figure 1.
Figure 1.
Rab11-mediated endosomal recycling defects reduce cell surface expression of McLeod syndrome protein XK and Mn transport in striatal neurons in HD.
See this image and copyright information in PMC

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References

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