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Comment
. 2022 Sep 15;29(9):1363-1365.
doi: 10.1016/j.chembiol.2022.08.002.

Ferroptosis execution: Is it all about ACSL4?

Hyemin Lee  1 , Boyi Gan  2
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Comment

Ferroptosis execution: Is it all about ACSL4?

Hyemin Lee et al. Cell Chem Biol. .
Free article

Abstract

ACSL4 is generally considered to be universally required for ferroptosis, a form of cell death induced by phospholipid peroxidation. In this issue of Cell Chemical Biology, Magtanong et al. (2022) report the surprising finding that ACSL4 is only required for ferroptosis in certain circumstances, raising interesting questions about the regulation of this cell death pathway.

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Conflict of interest statement

Declaration of interests B.G. is an inventor on patent applications involving targeting ferroptosis in cancer therapy.

Comment on

  • Context-dependent regulation of ferroptosis sensitivity.
    Magtanong L, Mueller GD, Williams KJ, Billmann M, Chan K, Armenta DA, Pope LE, Moffat J, Boone C, Myers CL, Olzmann JA, Bensinger SJ, Dixon SJ. Magtanong L, et al. Cell Chem Biol. 2022 Sep 15;29(9):1409-1418.e6. doi: 10.1016/j.chembiol.2022.06.004. Epub 2022 Jul 8. Cell Chem Biol. 2022. PMID: 35809566 Free PMC article.

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