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Comment
. 2022 Sep 15;82(18):3318-3320.
doi: 10.1016/j.molcel.2022.08.020.

Resonating with the signaling bias of CXCR7

Parishmita Sarma  1 , Arun K Shukla  2
Affiliations
Comment

Resonating with the signaling bias of CXCR7

Parishmita Sarma et al. Mol Cell. .

Abstract

Kleist et al. combine NMR spectroscopy and residue contact network analysis to identify a potential allosteric network in CXCR7, a β-arrestin-biased chemokine receptor, which links the extracellular ligand-binding pocket and the intracellular transducer-coupling region through the receptor transmembrane core.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1. An allosteric connection for CXCR7 activation and βarr coupling
(A) Schematic representation showing the intrinsically biased nature of CXCR7 compared to prototypical GPCRs. (B) A proposed allosteric pipeline that links the ligand-binding pocket on the extracellular side of the receptor to βarr-coupling interface on the cytoplasmic side through Asn127 localized in the transmembrane core of the receptor upon agonist binding (right panel) but not for antagonist (left panel).
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