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Comment
. 2022 Sep 15;82(18):3318-3320.
doi: 10.1016/j.molcel.2022.08.020.

Resonating with the signaling bias of CXCR7

Parishmita Sarma  1 , Arun K Shukla  2
Affiliations
Comment

Resonating with the signaling bias of CXCR7

Parishmita Sarma et al. Mol Cell. .

Abstract

Kleist et al. combine NMR spectroscopy and residue contact network analysis to identify a potential allosteric network in CXCR7, a β-arrestin-biased chemokine receptor, which links the extracellular ligand-binding pocket and the intracellular transducer-coupling region through the receptor transmembrane core.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1. An allosteric connection for CXCR7 activation and βarr coupling
(A) Schematic representation showing the intrinsically biased nature of CXCR7 compared to prototypical GPCRs. (B) A proposed allosteric pipeline that links the ligand-binding pocket on the extracellular side of the receptor to βarr-coupling interface on the cytoplasmic side through Asn127 localized in the transmembrane core of the receptor upon agonist binding (right panel) but not for antagonist (left panel).
See this image and copyright information in PMC

Comment on

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