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Comment
. 2022 Sep 15;185(19):3459-3461.
doi: 10.1016/j.cell.2022.08.013.

Team victory, yellow helmets for a computational tour de force

Catherine M Phelps  1 , Marlies Meisel  2
Affiliations
Comment

Team victory, yellow helmets for a computational tour de force

Catherine M Phelps et al. Cell. .

Abstract

Changes in the gut microbiota are associated with the etiopathogenesis of complex diseases, such as multiple sclerosis. In this issue of Cell, the international Multiple Sclerosis Microbiome Study consortium deployed a multi-omics approach to profile the composition and function of the gut microbiome in an extensive cohort of MS patients.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. Goals of the iMSMS consortium
The iMSMS mission consists of four goals: (1) uncover the MS-associated gut microbiome, (2) test the causal implications of differentially abundant species in gnotobiotic studies, (3) determine the molecular mechanisms that dictate crosstalk between the microbiota, the immune system, and the nervous system, and (4) apply these findings in clinical trials. The ambitious mission of the iMSMS consortium is to not only better conceptually understand the role of the gut microbiota in MS but also to identify potential microbial targets that can be tested in preclinical studies which will aid in designing clinical trials that assess the effectivity of novel microbial-based therapeutic avenues to cure MS.
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References

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