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. 2022 Sep 16;22(1):412.
doi: 10.1186/s12872-022-02829-w.

Haemodynamic determinants of quality of life in chronic heart failure

Serlie Fatrin #  1 , Nduka C Okwose #  1   2 , Kristian Bailey  3 , Lazar Velicki  4 , Dejana Popovic  5 , Arsen Ristic  5 , Petar M Seferovic  5 , Guy A MacGowan  1   3 , Djordje G Jakovljevic  6   7
Affiliations

Haemodynamic determinants of quality of life in chronic heart failure

Serlie Fatrin et al. BMC Cardiovasc Disord. .

Abstract

Background: Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic response to exercise and QOL in chronic heart failure.

Methods: A single-centre prospective study recruited 42 chronic heart failure patients (11 females, mean age 60 ± 10 years) with reduced left ventricular ejection fraction (LVEF = 23 ± 7%). All participants completed a maximal graded cardiopulmonary exercise test with non-invasive hemodynamic (bioreactance) monitoring. QOL was assessed using Minnesota Living with Heart Failure Questionnaire.

Results: The average value of QOL score was 40 ± 23. There was a significant negative relationship between the QOL and peak O2 consumption (r = - 0.50, p ≤ 0.01). No significant relationship between the QOL and selected exercise hemodynamic measures was found, including peak exercise cardiac power output (r = 0.15, p = 0.34), cardiac output (r = 0.22, p = 0.15), and mean arterial blood pressure (r = - 0.08, p = 0.60).

Conclusion: Peak O2 consumption, but not hemodynamic response to exercise, is a significant determinant of QOL in chronic heart failure patients.

Keywords: Exercise haemodynamics; Heart failure; Quality of life.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Relationship between quality-of-life score and metabolic and haemodynamic response to exercise in chronic heart failure patients: A peak oxygen consumption, B peak arteriovenous oxygen difference, C peak cardiac output, D peak cardiac power output
See this image and copyright information in PMC

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