Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Jan;78(1):e20-e22.
doi: 10.1016/j.jhep.2022.08.039. Epub 2022 Sep 15.

In situ detection of vaccine mRNA in the cytoplasm of hepatocytes during COVID-19 vaccine-related hepatitis

Loreto Martin-Navarro  1 , Carlos de Andrea  2 , Bruno Sangro  3 , Josepmaria Argemi  4
Affiliations
Comment

In situ detection of vaccine mRNA in the cytoplasm of hepatocytes during COVID-19 vaccine-related hepatitis

Loreto Martin-Navarro et al. J Hepatol. 2023 Jan.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
In situ SARS-CoV-2 mRNA measurement using quantitative fluorescence and patient's biochemical tests. SARS-CoV-2 mRNA transcripts (yellow channel) were detected using in situ hybridization in (A) the liver of an individual with hepatitis after the second dose of the Pfizer-BioNTech (BNT162b2) vaccine, (B) a post-mortem liver tissue from an individual diagnosed with severe COVID-19 (as a positive control). (C and D) No SARS-CoV-2 mRNA transcripts were detected in the liver tissues from individuals with autoimmune hepatitis unrelated to COVID-19. Nuclei are highlighted with blue. Scale bars represent 200 μm (A-D). (E) Patient’s course of AST, ALT, total bilirubin, ALP and GGT activity. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma glutamyltransferase.
See this image and copyright information in PMC

Comment on

  • SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis.
    Boettler T, Csernalabics B, Salié H, Luxenburger H, Wischer L, Salimi Alizei E, Zoldan K, Krimmel L, Bronsert P, Schwabenland M, Prinz M, Mogler C, Neumann-Haefelin C, Thimme R, Hofmann M, Bengsch B. Boettler T, et al. J Hepatol. 2022 Sep;77(3):653-659. doi: 10.1016/j.jhep.2022.03.040. Epub 2022 Apr 21. J Hepatol. 2022. PMID: 35461912 Free PMC article.

References

    1. Boettler T., Csernalabics B., Salié H., Luxenburger H., Wischer L., Alizei E.S., et al. SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis. J Hepatol. 2022;77:653–659. doi: 10.1016/j.jhep.2022.03.040. - DOI - PMC - PubMed
    1. Rüther D.F., Weltzsch J.P., Schramm C., Sebode M., Lohse A.W. Autoimmune hepatitis and COVID-19: No increased risk for AIH after vaccination but reduced care. J Hepatol. 2022 Jul;77(1):250–251. doi: 10.1016/j.jhep.2022.02.013. Epub 2022 Mar 10. PMID: 35282896; PMCID: PMC8908797. - DOI - PMC - PubMed
    1. Rena M., Jothimani D, Vij M., Rajakumar A., Rammohan A. Autoimmune hepatitis following COVID vaccination. J Autoimmun. 2021;123 doi: 10.1016/j.jaut-2021.102688. - DOI - PubMed
    1. Londoño M.C., Gratacós-Ginès J., Sáez-Peñataro J. Another case of autoimmune hepatitis after SARS-CoV2 vaccination. Still casuality? J Hepatol. 2021;75:1248–1249. doi: 10.1016/j.jhep.2021.06.004. - DOI - PMC - PubMed
    1. Shroff H., Satapathy S.K., Crawford J.M., Todd N.J., VanWagner L.B. Liver injury following SARS-CoV-2 vaccination: a multicenter case series. J Hepatol. 2022;76(1):211–214. doi: 10.1016/j.jhep.2021.07.024. - DOI - PMC - PubMed