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. 2020 Dec 17;13(2):189-201.
doi: 10.1016/j.chmed.2020.12.005. eCollection 2021 Apr.

Network pharmacology unveils spleen-fortifying effect of Codonopsis Radix on different gastric diseases based on theory of "same treatment for different diseases" in traditional Chinese medicine

Ru-Pu He  1 , Zheng Jin  1 , Ru-Yun Ma  1 , Fang-di Hu  1 , Jian-Ye Dai  1
Affiliations

Network pharmacology unveils spleen-fortifying effect of Codonopsis Radix on different gastric diseases based on theory of "same treatment for different diseases" in traditional Chinese medicine

Ru-Pu He et al. Chin Herb Med. .

Abstract

Objective: "Same treatment for different diseases" is a unique treatment strategy under the guidance of traditional Chinese medicine (TCM) theory. Codonopsis Radix (Codonopsis pilosula, Dangshen in Chinese) with spleen-fortifying effect was employed to understand the strategy of "Same treatment for different diseases", based on its common mechanism in the treatment of gastric diseases including gastric ulcer, gastritis and gastric cancer via network pharmacology research.

Methods: Network pharmacology research methods were used to analyze the interaction network and potential mechanisms of Dangshen in treating gastric ulcer, gastritis and gastric cancer. The active components and their target proteins of Dangshen were integrated from TCMSP, BATMAN-TCM databases. The targets of gastric ulcer, gastritis and gastric cancer were collected through GeneCards, PubMed, TDD and DisGeNET Database. Through screening, the key components and the key targets of Dangshen in treating gastric ulcer, gastritis and gastric cancer were obtained. After KEGG pathway analysis and GO analysis, the important pathways and biological processes were analyzed.

Results: Through data and literature mining, the common and specific pharmaceutical effects and mechanism of Dangshen were summarized in these three gastric lesions. It was shown that Dangshen mainly acted on gastric ulcer, gastritis and gastric cancer through the overall regulation of the PI3K-AKT signaling pathway. With the development of the disease, it will gradually increase the control of inflammation through TNF, NF-κB and other inflammation-related signaling pathways to reduce inflammatory damage. For tumorigenesis, it pays more attention to inhibiting the ErbB signaling pathways to reduce the proliferation and migration of tumor cells. In addition, Dangshen's regulation of HIF-1 signaling pathway may also be beneficial for the treatment of gastric ulcer, gastritis and gastric cancer.

Conclusion: Dangshen achieves spleen-fortifying effect on gastric diseases including gastric ulcer, gastritis and gastric cancer through multiple targets in multiple pathways, especially PI3K-AKT pathway and HIF-1 pathway. It could provide a scientific basis for understanding the strategy of "Same treatment for different diseases" in traditional Chinese medicine.

Keywords: Codonopsis Radix; gastric cancer; gastric ulcer; gastritis; network pharmacology; same treatment for different diseases; spleen-fortifying effect.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Compound-target network of Dangshen.
Fig. 2
Fig. 2
PPI network of Dangshen in treatment of gastric ulcer.
Fig. 3
Fig. 3
PPI network of Dangshen in treatment of gastritis.
Fig. 4
Fig. 4
PPI network of Dangshen in treatment of gastric cancer.
Fig. 5
Fig. 5
Network of Dangshen – key components – key targets – important pathways – gastric ulcer.
Fig. 6
Fig. 6
Targets prediction of Dangshen in gastric ulcer by pathway analysis (A) and GO analysis (B).
Fig. 7
Fig. 7
Network of Dangshen-key components-key targets-important pathways-gastritis.
Fig. 8
Fig. 8
Targets prediction of Dangshen in gastritis by pathway analysis (A) and GO analysis (B).
Fig. 9
Fig. 9
Network of Dangshen-key components-key targets-important pathways-gastric cancer.
Fig. 10
Fig. 10
Targets prediction of Dangshen in gastric cancer by pathway analysis (A) and GO analysis (B).
Fig. 11
Fig. 11
Schematic diagram of spleen-fortifying effect of Dangshen on three gastric lesion.
See this image and copyright information in PMC

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